Results 51 to 60 of about 809,191 (273)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Optimal Photon Generation from Spontaneous Raman Processes in Cold Atoms [PDF]

open access: yes, 2017
Spontaneous Raman processes in cold atoms have been widely used in the past decade for generating single photons. Here, we present a method to optimize their efficiencies for given atomic coherences and optical depths.
de Riedmatten, Hugues   +3 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Spontaneous Multi‐Interface Modulation for Enhancing Organic Transistor Performance via Self‐Generated Molecular Interlayers

open access: yesSmall Structures
The interfacial properties between source/drain electrodes and the active layer, as well as between the gate dielectric and the active layer, are critical determinants of the performance and operational stability of organic field‐effect transistors ...
Hansol Lee   +8 more
doaj   +1 more source

Chondrogenic Differentiation of Porcine Skin-Derived Stem Cells with Different Characteristics of Spontaneous Adipocyte Formation

open access: yesJournal of Animal Reproduction and Biotechnology, 2017
The purpose of this study is to confirm whether spontaneous adipocyte generation during chondrogenic induction culture affects the chondrogenic differentiation of porcine skin-derived stem cells (pSSCs).
Hyo-Kyung Bae   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Using a Human Interviewer or an Automatic Interviewer in the Evaluation of Patients with AD from Speech

open access: yesApplied Sciences, 2021
Currently, there are more and more frequent studies focused on the evaluation of Alzheimer’s disease (AD) from the automatic analysis of the speech of patients, in order to detect the presence of the disease in an individual or for the evolutionary ...
Jesús B. Alonso-Hernández   +4 more
doaj   +1 more source

Spontaneous Nambu-Goldstone Currents Generation Driven by Mismatch

open access: yes, 2006
We review recent progress of understanding and resolving instabilities driven by mismatch between the Fermi surfaces of the pairing quarks in 2-flavor color superconductor.
Huang, Mei
core   +2 more sources

Spontaneous generation of mammalian prions [PDF]

open access: yesProceedings of the National Academy of Sciences, 2010
Prions are transmissible agents that cause lethal neurodegeneration in humans and other mammals. Prions bind avidly to metal surfaces such as steel wires and, when surface-bound, can initiate infection of brain or cultured cells with remarkable efficiency.
Julie A, Edgeworth   +9 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

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