Results 81 to 90 of about 809,191 (273)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Non-perturbative solutions in the electro-weak theory with $\bar t t$ condensate and the $t$-quark mass

, 2011
We apply Bogoliubov compensation principle to the gauge electro-weak interaction to demonstrate a spontaneous generation of anomalous three-boson gauge invariant effective interaction.
Bateman H., Bogoliubov N. N., Bogoliubov N. N., BORIS A. ARBUZOV, IVAN V. ZAITSEV   +4 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Experimental observation of a chaos-to-chaos transition in laser droplet generation

, 2010
We examine the dynamics of laser droplet generation in dependence on the detachment pulse power. In the absence of the detachment pulse, undulating pendant droplets are formed at the end of a properly fed metal wire due to the impact of the primary laser
Govekar, Edvard, Krese, Blaz, Perc, Matjaz   +2 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

An Alternative Approach to Spontaneous Photon Triplets Generation

Advanced Physics Research
An alternative quantum approach to quasinormal modes is based on the very recently introduced formalism of generalized photon creation and annihilation operators.
Serge Gauvin
doaj   +1 more source

Spontaneous Flux and Magnetic Interference Patterns in 0-pi Josephson Junctions

, 1997
The spontaneous flux generation and magnetic field modulation of the critical current in a 0-pi Josephson junction are calculated for different ratios of the junction length to the Josephson penetration depth, and different ratios of the 0-junction ...
A. G. Sun, A. S. Katz, C. O’Donovan, C. S. Owen, D. A. Wollman, D. J. Scalapino, D. J. Scalapino, D. J. van Harlingen, J. F. Annett, J. H. Miller, Jr., J. H. Xu, J. R. Kirtley, J. R. Kirtley, K. A. Moler, M. B. Walker, M. Sigrist, R. Kleiner, S. R. Bahcall   +17 more
core   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source