Results 61 to 70 of about 6,486,745 (293)

mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity [PDF]

Psychopharmacology, 2019
A role of group I metabotropic glutamate receptor 5 (mGlu5) in regulating spontaneous locomotion and psychostimulant-induced hyperactivity has been proposed.This study aims to determine if mGlu5 in GABAergic neurons regulates spontaneous or psychostimulant-induced locomotion.We generated mice specifically lacking mGlu5 in forebrain GABAergic neuron by ...
Chia-Shan Wu, Christopher P. Jew, Hao Sun, Carlos J. Ballester Rosado, Hui-Chen Lu   +4 more
openaire   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Effect of amiloride: An Na + / H + exchange inhibitor in the middle cerebral artery occlusion model of focal cerebral ischemia in rats

Journal of Pharmacy and Bioallied Sciences, 2011
Purpose : The effect of pretreatment with amiloride (AML), an Na + / H + exchange inhibitor was studied in the middle cerebral artery occlusion (MCAO) model of focal cerebral ischemia in rats.
Mohammad Akhtar, K K Pillai, Abul Kalam Najmi, Divya Vohora   +3 more
doaj   +1 more source

Spontaneous and METH-stimulated locomotor activity in wildtype (WT) and ICER knockout (KO) mice.

, 2013
METH (1 mg/kg) was administered once per day on Days 1, 3, 5, 7, 9, 13, and 20 in WT (n = 13) and ICER-KO (n = 13) mice. a. ime-course of spontaneous locomotor activity before and after METH administration on Day 1.
Hideko Yamamoto (238832), Nobuhiko Kojima (349190), Shinya Kasai (238826), Kazutaka Ikeda (142226), Tomoaki Shirao (349188), Shogo Endo (308769), Wenhua Han (238829), Yukio Takamatsu (349184)   +7 more
core   +1 more source

The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine [PDF]

, 2013
The effects of the non-NMDA glutamate receptor antagonist GYKI 52466 (2.4 and 4.8 mg/kg, i.p.) on spontaneous locomotor activity and haloperidol-induced catalepsy (0.5 mg/kg, i.p.) were assessed in naive rats and in rats pretreated with the NMDA ...
Hauber, Wolfgang, Andersen, Ragna
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Using in vivo calcium imaging to examine joint neuron spontaneous activity and home cage analysis to monitor activity changes in mouse models of arthritis

Arthritis Research & Therapy
Background Studying pain in rodent models of arthritis is challenging. For example, assessing functional changes in joint neurons is challenging due to their relative scarcity amongst all sensory neurons.
George L. Goodwin, Alina-Cristina Marin, Julia Vlachaki Walker, Carl Hobbs, Franziska Denk   +4 more
doaj   +1 more source

Influence of time-of-day on maximal exercise capacity is related to daily thermal balance but not to induced neuronal activity in rats

Frontiers in Physiology, 2016
In the present study, we investigated whether the daily fluctuations of internal body temperature (Tb) and spontaneous locomotor activity (SLA) interact with the thermal and neuronal adjustments induced by high-intensity aerobic exercise until fatigue ...
Frederico Sander Mansur Machado, Daniela Rocha Costa Fóscolo, Maristela Oliveira Poletini, Cândido Celso Coimbra   +3 more
doaj   +1 more source

3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations

Frontiers in Physiology, 2020
Dysfunctions of kynurenine pathway of tryptophan metabolism (KPTM) are associated with multiple neuropathologies in vertebrates and invertebrates.
Aleksandr V. Zhuravlev, Oleg V. Vetrovoy, Oleg V. Vetrovoy, Polina N. Ivanova, Polina N. Ivanova, Elena V. Savvateeva-Popova   +5 more
doaj   +1 more source

Central effects of tumor factor alfa and interleukin-1a on nociceptive thresholds and spontaneous locomotor activity

, 1992
To extend the knowledge on the central effects of cytokines, we studied the effects of tumor necrosis factor α and interleukin-1α on nociceptive thresholds and spontaneous locomotor activity in rats.
P. Ricciardi Castagnoli, M.Bianchi, A.E. Panerai, P. Mantegazza, P. Sacerdote   +4 more
core   +1 more source