Results 71 to 80 of about 6,486,745 (293)
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
Effects of Two Types of Restraint Stress on the Spontaneous Behaviour in Rats
Acta Medica, 2004 Our previous findings suggested the existence of stressor-specific behavioural and cognitive responses in rats. In the present study, restraint stressor (immobilization, IMO) and restraint stressor combined with partial immersion of rats into water (IMO ...
Lenka Trnečková +5 more
doaj +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Obesity and the Neuroendocrine Control of Energy Homeostasis: The Role of Spontaneous Locomotor Activity [PDF]
The Journal of Nutrition, 2005 Obesity represents one of the most urgent global health threats as well as one of the leading causes of death throughout industrialized nations. Efficacious and safe therapies remain at large. Attempts to decrease fat mass via pharmacological reduction of energy intake have had limited potency or intolerable side effects.
Tamara R, Castañeda +7 more
openaire +2 more sources
From Folding Mechanics to Robotic Function: A Unified Modeling Framework for Compliant Origami
Advanced Science, EarlyView.A geometry‐consistent DDG framework captures compliant origami deformation from rigid‐like folding to soft panel bending. By tuning crease and panel stiffness, bistable snap‐through responses transform into smooth monostable deformation, enabling programmable stability and robot‐scale locomotion.
Bohan Zhang +7 more
wiley +1 more source
Effects of new nitric oxide synthase inhibitors on spontaneous locomotor activity
Medicinski pregled, 2006 Introduction. New nitric oxide synthase (NOS) inhibitors: 3-bromo-7-nitro- indazole (3-Br-7-NI), 1-(2-trifluoromethylphenyl) imidazole (TRIM), S-methyl-L-thiocitrulline (S-Me-TC) and 7-nitroindazole (7-NI) reduce spontaneous locomotor activity in mice. Material and methods.
Eleonora, Dzoljić +5 more
openaire +3 more sources
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Effect of Strychnine Sulfate on Locomotor Activity
, 1965 The effect of strychnine sulfate upon spontaneous locomotor activity in an open field was determined for 20 naive male Wistar rats. The experimental Ss were injected ip with 1.0 cc/kg of a 01% solution of strychnine sulfate in normal saline and the ...
George B. Kish +2 more
core +1 more source
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
Spontaneous locomotor activity revealed parkinsonian phenotype.
, 2014 The upper row (A) depicts spontaneous 23h locomotor activity of a representative control rat, the lower row (B) of an example PD rat. Recordings were performed before (left) and after 6-OHDA or vehicle injections (left-middle) as well as before (right ...
Andrew Sharott (534318) +11 more
core +1 more source