Results 171 to 180 of about 417,137 (292)

Spontaneous Regression of Metastatic Colorectal Cancer Following Discontinuation of an Interleukin-6 Receptor Inhibitor: A Case Report. [PDF]

Surg Case Rep
Miyake E, Taniguchi F, Nosaka M, Mouri K, Sato M, Kajioka H, Ogawa T, Watanabe M, Katsuda K, Iseki A, Sato Y, Tanakaya K, Aoki H.   +12 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Lung Adenocarcinoma Diagnosed in a Nodule After Initial Spontaneous Regression in Size. [PDF]

Respirol Case Rep
Mo L, Boas FV, Martin S, Rajanayagam J, Pretorius V.   +4 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Spontaneous Regression of Pediatric Osteochondroma: Clinical Case and Comprehensive Literature Review. [PDF]

Cureus
Matsumoto K, Ishimaru D, Sohmiya K, Terabayashi N.   +3 more
europepmc   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Bladder masses simulating neoplasia in chronic granulomatous disease: Diagnostic challenges and spontaneous regression. [PDF]

Urol Case Rep
Dadpour M, Soleimanifard N, Alishah S, Chalaki M.   +3 more
europepmc   +1 more source

Organic Crystal‐MXene Composites as Temperature‐Tolerant Strain Sensors

Advanced Science, EarlyView.
ABSTRACT Flexible organic crystals offer significant opportunities for organic electronics; however, their potential applications in fields like flexible sensors are at present limited by poor charge transport that result in failure under reversible conditions.
Xuesong Yang, Lijie Wang, Shun Liu, Yuhan Zhang, Yongqiang Xu, Haixia Mei, Liang Li, Ying Tao, Quan‐Hong Yang, Panče Naumov, Hongyu Zhang   +10 more
wiley   +1 more source

Spontaneous regression of a broad-based protruded cervical disc: A case report and review of the literature. [PDF]

Surg Neurol Int
Tokar S, Arslan M, Akyol ME.
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source