Results 101 to 110 of about 41,451 (188)

Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations [PDF]

, 2012
Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies.
Bryceson, Yenan T., Chiang, Samuel C.C., Gustafsson, Britt, Henter, Jan-Inge, Klimkowska, Monika, Machaczka, Maciej, Martha-Lena, Müller, Meeths, Marie   +7 more
core   +1 more source

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source

C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]

, 2012
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph, Lehnert, Mark, Lemasters, John J., Maldonado, Eduardo N., Marzi, Ingo, Theruvath, Tom Prakash, Zhong, Zhi   +6 more
core   +2 more sources

Engineered CAR‐T–Derived Exosomes Co‐Delivering miR‐145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Ruyue Yang, Haitao Wang, Guidan Wang, Gankun Yuan, Zhaoyi Wei, Junling An, Dong Hu, Wenjing Wen, Shegan Gao, Yuan Wan, Gaofeng Liang   +10 more
wiley   +1 more source

Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma

Case Reports in Oncological Medicine, 2017
Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities.
Shinichi Harada, Keiki Nagaharu, Youichirou Baba, Tetsuya Murata, Toshiro Mizuno, Keiki Kawakami   +5 more
doaj   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Clinical Aspects of Feline Retroviruses: A Review [PDF]

, 2012
Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease.
Ackley, Anderson, Barlough, Barnett, Barr, Beatty, Beatty, Beatty, Bishop, Bishop, Brightman, Brown, Callanan, Callanan, Carmichael, Choi, Cotter, Cotter, Cotter, Court, Cullen, Day, Dean, Diehl, Dow, Ellis, English, Essex, Fleming, Flynn, Francis, Garg, Gunn-Moore, Hara, Hardy, Harrus, Heit, Hoffmann-Fezer, Hofmann-Lehmann, Holznagel, Hoover, Hoover, Hutson, Jackson, Jarrett, Johnson, Joshi, Katrin Hartmann, Kipar, Kohn, Kubes, Lauring, Levy, Levy, Levy, Liang, Linenberger, Lott-Stolz, Matsumoto, Mitchell, Mizuno, Mizuno, Mizuno, Mortola, Mortola, Novotney, O'Connor, Ohno, Ohno, Overbaugh, Pedersen, Pedersen, Phillips, Phipps, Podell, Podell, Pool, Power, Prospero-Garcia, Quackenbush, Reinacher, Rickard, Ritchey, Rohn, Schrenzel, Sellon, Sellon, Sheets, Shelton, Shelton, Shimojima, Shimojima, Stiles, Taniguchi, Tompkins, Torten, Tsatsanis, Willett, Willett, Zaccaro, Zhao   +100 more
core   +3 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene [PDF]

, 2017
Timeline. This file shows timeline of both described cases.
Anna Seehofnerova, Elleni Michu, Jakub Neradil, Jana Soukalova, Jaroslav Sterba, Kristyna Melicharkova, Marta Jezova, Ondrej Rohleder, Ondrej Slaby, Peter Mudry, Renata Veselska   +10 more
core   +2 more sources

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, Volume 22, Issue 16, 17 March 2026.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source