Results 91 to 100 of about 6,976 (171)

Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare

Genome Medicine, 2018
Editorial summary Evidence has recently been reported of prion seeding activity in skin tissue from patients with sporadic Creutzfeldt-Jakob disease (sCJD). This is relevant information for infection control measures during surgery.
Akin Nihat, Simon Mead
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Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Emerging Infectious Diseases, 2012
We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion
Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, Thierry Baron   +5 more
doaj   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
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Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Emerging Infectious Diseases, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green   +8 more
doaj   +1 more source

Autoantibodies in sporadic Creutzfeldt-Jakob disease.

, 2013
IMPORTANCE: The diagnosis of autoimmune and neurodegenerative conditions can be unclear. Treatments such as removing the associated tumor, if present, and immunosuppression can halt or often reverse the progression of autoimmune conditions, but there is ...
Angus-Leppan, H, Rudge, P, Collinge, J, Mead, S, Vincent, Angela   +4 more
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All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD [PDF]

, 2011
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the ...
Smith, Antony, Ian R. MacGregor, Groschup, Martin H., Hunter, N., Hunter, Nora, Prowse, C.V., Tan, B.C., Hornsey, V.S., Boon Chin Tan, Sandra McCutcheon, Jean C Manson, Antony Smith, E. Fiona Houston, Jean C. Manson, Alejo-Blanco, Richard, Manson, J.C., Tan, Boon Chin, Turner Marc, Manson, Jean C., Houston E. Fiona, Alejo Blanco, A.R., Turner, Marc, Groschup Martin H., MacGregor, Ian R., Houston, Fiona, Christopher V Prowse, Turner, M., E Fiona Houston, Alejo Blanco Anthony Richard, Groschup, M.H., Martin H Groschup, Smith Antony, de Wolf, C., Christopher V. Prowse, Hunter Nora, Prowse, Christopher V., Christopher de Wolf, Anthony Richard Alejo Blanco, MacGregor Ian R., de Wolf Christopher, Marc Turner, de Wolf, Christopher, Valerie S. Hornsey, Smith, A., Manson Jean C., Prowse Christopher V., Ian R MacGregor, Prowse, C. V., Hornsey, Valerie S., McCutcheon Sandra, MacGregor, I.R., McCutcheon, Sandra, Nora Hunter, Tan Boon Chin, Hornsey Valerie S., Martin H. Groschup, McCutcheon, S., Houston, E.F., Valerie S Hornsey   +58 more
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Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease

, 2017
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype.
Taratuto, A., Meissner, B., Brandel, J. P., Varges, D., Smith, P., Romero, C., Collie, D., Begue, C., Summers, D. M., Pocchiari, M., Collins, S. J., Ladogana, A., Will, R. G., Haik, S., Heinemann, U., Zerr, I., Breithaupt, M., Hewer, E., Roberts, H., van Duijn, C., Jansen, Gerard H., Kallenberg, K., Sanchez-Juan, P., Schuur, M., Cras, P., Stokin, G. B., Pimentel, J.   +26 more
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Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: U.K. cases 1991-2002

, 2004
Human prion diseases can occur as an idiopathic disorder (sporadic Creutzfeldt–Jakob disease) or can be acquired, as is the case for variant Creutzfeldt–Jakob disease.
MacKenzie, Jan, McCardle, Linda, Knight, Richard, McKimmie, Clive S., McLoughlin, Victoria, Bunn, Tristan J. R., Head, Mark W., Bishop, Matthew T., Williams, Michelle C., Will, Robert G., Lowrie, Suzanne, Ironside, James W.   +11 more
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Genome-wide association study of behavioural and psychiatric features in human prion disease.

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
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Sporadic Creutzfeldt–Jakob disease

, 2018
Sporadic Creutzfeldt-Jakob disease (CJD), the most common human prion disease, is generally regarded as a spontaneous neurodegenerative illness, arising either from a spontaneous PRNP somatic mutation or a stochastic PrP structural change. Alternatively,
Zerr, Inga, Inga Zerr, Piero Parchi, Parchi, Piero   +3 more
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