Results 41 to 50 of about 546,299 (291)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analysis of the Sporadic-E Layer Behavior in Different American Stations during the Days around the September 2017 Geomagnetic Storm

Atmosphere, 2022
The development of sporadic-E (Es) layers over five Digisonde stations in the American sector is analyzed. This work aims to investigate the dynamic of such layers during the days around the geomagnetic storm that occurred on 8 September 2017. Therefore,
Laysa C. A. Resende, Yajun Zhu, Christina Arras, Clezio M. Denardini, Sony S. Chen, Juliano Moro, Diego Barros, Ronan A. J. Chagas, Lígia A. Da Silva, Vânia F. Andrioli, José P. Marchezi, Alexander J. Carrasco, Chi Wang, Hui Li, Zhengkuan Liu   +14 more
doaj   +1 more source

Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin's Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. [PDF]

, 2015
Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers.
Alfieri, R, Amadori, Alberto, Boldrin, E, Cagol, M, Cappellesso, Rocco, Castoro, C, Chiarion Sileni, V, Fassan, Matteo, Rugge, Massimo, Rumiato, E, Ruol, A, Saggioro, D.   +11 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Simultaneous lidar observations of the sporadic Ni layer and sporadic Na layer in the MLT

Earth and Planetary Physics
Here we report on simultaneous lidar observations of sporadic Ni (Nis) layers and sporadic Na (Nas) layers in the atmosphere over Yanqing, Beijing (40.42°N, 116.02°E) from April 2019 to October 2022.
ZhiJun Zhao, XuYang Jiang, FuJu Wu, YuHang Qi, Jing Jiao, GuoTao Yang   +5 more
doaj   +1 more source

Surgical treatment of sporadic vestibular schwannoma in a series of 1006 patients. Trattamento chirurgico degli schwannomi vestibolari: risultati su una serie di 1006 pazienti [PDF]

, 2016
La gestione dello schwannoma vestibolare (SV) sporadico si è gradualmente evoluta negli ultimi decenni. Lo scopo di questo studio è di analizzare l’evoluzione negli esiti chirurgici dell’exeresi di queste lesioni, realizzata da un team neurotologico tra
BERNARDESCHI, DANIELE, DE SETA, DANIELE, Kalamarides, M, Nguyen, Y, Rey, A, RUSSO, FRANCESCA YOSHIE, Sterkers, O, Zhang, Z   +7 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Modulation of sporadic E layers by small-scale atmospheric waves in Earth’s high-latitude ionosphere

Solar-Terrestrial Physics, 2019
We have used radio occultation measurements of the satellite CHAMP (Challenging Minisatellite Payload) to examine sporadic E layers (altitudes 90–130 km) in Earth’s high-latitude ionosphere.
Gubenko V.N., Kirillovich I.A.
doaj   +1 more source

Maass-Jacobi Poincar\'e series and Mathieu Moonshine [PDF]

, 2015
Mathieu moonshine attaches a weak Jacobi form of weight zero and index one to each conjugacy class of the largest sporadic simple group of Mathieu. We introduce a modification of this assignment, whereby weak Jacobi forms are replaced by semi-holomorphic
Bringmann, Kathrin, Duncan, John, Rolen, Larry   +2 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source