Results 91 to 100 of about 1,934,866 (340)

Canadian national sport organisations’ use of the web for relationship marketing in promoting sport participation [PDF]

open access: yes, 2009
Sport participation development requires a systematic process which involves knowledge creation, dissemination and interactions between National Sport Organisations, participants, clubs and associations as well as other agencies.
Boucher, B   +5 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Children’s Sport Participation in Canada: Is it a Level Playing Field? [PDF]

open access: yes, 2007
In this article a study of children’s sport participation in Canada is presented, examining both children’s participation in organized sport (with a coach or instructor) and informal sport (without a coach or instructor).
McTeer, William, Trussell, Dawn E.
core   +1 more source

Examination of a Screening Tool for Athletes’ Mental Health and its Direct Implications to Sport Training and Competition

open access: yes, 2018
The Sport Interference Checklist (SIC) is a psychometrically validated instrument designed to assess how often cognitive and behavioral factors interfere with athletes performance during training and/or competition as well as the extent to which athletes
Scott, Jesse
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

A lesson learned in time: Advice shared by experienced sport psychologists [PDF]

open access: yes, 2015
Through experience, sport psychologists will learn countless valuable lessons. Some lessons, however, are likely to stand out vividly to a psychologist because they made a valuable difference to how they practise.
McCormick, Alister, Meijen, Carla
core   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

After-school sport for children: Implications of a task-involving motivational climate [PDF]

open access: yes, 2005
It could be argued that youth sport is one of the most pervasive and popular activities engaging girls and boys in their “free time ” in contemporary American society.
Duda, Joan L, Ntoumanis, Nikos
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

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