Results 91 to 100 of about 1,115,331 (279)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Club-based vs. hospital-guided rehabilitation after ACL reconstruction in football participants: a two-year prospective cohort study

Frontiers in Sports and Active Living
BackgroundAnterior cruciate ligament (ACL) injury is a common and serious sports injury in football. Although reconstruction surgery can restore joint stability, postoperative rehabilitation strategies play a critical role in long-term outcomes ...
Zhe Han, Peng Sun, Peng Sun, Peng Sun, Tianwu Chen, Yu Dong   +5 more
doaj   +1 more source

Reconsidering feminisms and the work of Norbert Elias for understanding gender, sport and sport-related activities [PDF]

, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2008 North West Counties Physical Education Association and SAGE Publications.This paper reconsiders the relationships between feminist ...
Mansfield, L, Mansfield, L.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The development of Swiss sports clubs: Membership, volunteering, professionalization

Current Issues in Sport Science
Introduction The Swiss Sports Observatory has been conducting the national club survey since 1996. Every six years, the club managers of all sports clubs belonging to an association affiliated to Swiss Olympic are asked to complete a questionnaire ...
Rahel Bürgi, Angela Gebert, Hanspeter Stamm, Markus Lamprecht   +3 more
doaj   +1 more source

Equipe de futebol feminino do Sport Club Internacional (2000)

, 2000
A fotografia foi cedida por Eduarda Marranghello Luizelli [Duda] que autorizou sua divulgação. A produção de registros sobre futebol feminino integra as atividades do Programa Futebol e Mulheres desenvolvido pelo Grupo de Estudos sobre Esporte, Cultura e
Sport Club Internacional
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

PROPOSED FANS' SOLUTIONS TO IMPROVE A SPORTS CLUB RESULTS IN PERIODS OF LOW SPORT PERFORMANCE [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
Sport has a universal magnetism, being present in all meridians of the world, at all times, and in all types of civilizations. Its attractiveness is manifested at the level of all demographic segments.
SANDU VLAD ANTONIUS , PĂSĂRIN LEONARDO DANIEL , COSTIN DAN EUGEN, POPA MARIAN GABRIEL , DIACONESCU DRAGOȘ LAURENȚIU, DUMITRU ROXANA, POPESCU MARIUS CĂTĂLIN   +6 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source