Results 101 to 110 of about 386,068 (293)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Factors Influencing The Development Of Organizational Sports (Case Study: Sari Municipality) [PDF]

Research in Sport Management and Marketing
Purpose: Considering the importance of sports in today's era and the necessity to use it by organizational employees; the current research was conducted to identify the effective factors on the development of sports in Sari Municipality.
Hossein Taheri, Seyed Jalal Hasanzadeh, Bahare Soleymani Tappesari, Elahe Heidarian Baei   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

CREATING A MODEL OF MANAGEMENT IN THE SECURITY SYSTEM OF SPORTS EVENTS [PDF]

Sport Mont, 2012
The acquired information and knowledge that the public in the sport events: from heterogeneous sport audience, media and sport superstructure to sports organizations relate to the security in a passive way, in an expectation that the risk of security ...
Dragan Đuranović, Srećko Novaković, Dejan Gligović   +2 more
doaj  

Sport as a driver for local development and sustainable tourism

Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2017
The paper analyses the relationship between sport and tourism. Starting from the literature on sport tourism and tourism sport, we examine the impact of a sporting event in terms of tourist flow in relation to the provision of sporting facilities in the ...
Anna Maria Pioletti
doaj   +1 more source

Conductas de practica deportiva y uso de instalaciones. Diferencias en función del tipo de practica [PDF]

, 1997
Este trabajo compara tres grupos de practicantes deportivos (deportistas de alto nivel, estudiantes de Educación Física y una muestra general de usuarios de instalaciones), en una serie de variables relacionadas con las actitudes ante la práctica ...
Añó Sanz, Vicente, Martínez-Tur, Vicente, Ramos, José   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A validity of the use of compositions on the basis of succinic acid in higher achievements sports. [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
A basic mechanism of influence on providing energy of muscular activity of succinic acid are analysed and the necessity of including in the complement of pharmacological facilities on her basis of other bioactive substances is reasonabled.
Gunina L.М.
doaj  

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source