Results 91 to 100 of about 831,003 (288)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Sports Facilities in Scotland; Survey of Sports Clubs Affiliated to National Governing Bodies, 1976
, 1988 copyright UK Data Service and data collection copyright owner.These data record the number and facilities of sports clubs affiliated to national governing bodies throughout ScotlandMain Topics:Variables Location; type of facility; type of sport played ...
Scottish Sports Council
core +3 more sources
Club Objectives and Ticket Pricing in Professional Team Sports [PDF]
In this paper we analyze and compare the behavior of sports clubs in a profit and a win maximization league if the decisions on the optimal ticket price and the talent demand have to be made simultaneously.
Wilfried Pauwels, Stefan Kesenne
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Lifestyle peculiarities of people exercising in the sports and wellness clubs at their leisure time. [PDF]
, 2008 The growing number of sports and wellness clubs and people exercising there should be the encouragement to take care of ourselves and our health in all aspects.
Jankauskas, Andrius,
core +1 more source
A Proposed Strategy for Managing Digital Public Relations for Private Sports Clubs [PDF]
Assiut Journal of Sport Science and ArtsResearch Objectives.The research aims to develop a proposed model for the strategy of digital public relations management in private sports clubs in the light of the following axes:1. Digital Public Relations Objectives.2.
Mona Sharif
doaj +1 more source
Some comparative economics of the organization of sports: competition and regulation in north American vs. European professional team sports leagues [PDF]
This article contends that a new research avenue is open to comparative economics which is the economic comparison between American (closed) and European (open) professional team sports leagues.
Wladimir Andreff
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source