Results 91 to 100 of about 323,027 (311)
Purpose: Municipalities play a crucial role in shaping local environments and opportunities for health-enhancing physical activity (HEPA), yet there is a lack of systematic, evidence-based assessment tools to guide and inform their efforts. By applying a
Luika, Signe +4 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Development and validation of the Sports Supplements Beliefs Scale [PDF]
, 2016 It has been proposed that the use of sports supplements by athletes might lead to the use of banned substances. This has been termed the gateway hypothesis.
Beedie, C. +3 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
GEOGRAPHY OF A SPORTS METROPOLIS [PDF]
This study analyzes the sports infrastructure of Hamburg, Germany, from the residents’ perspective. Empirical evidence is provided using a micro-level dataset of 1,319 sports facilities, which is merged with highly disaggregated data on population, socio-
Arne FEDDERSEN, Gabriel M. AHLFELDT
core
The speed dynamics of different sprint and acceleration exercises applied during football training
Scientific ReportsSprinting actions are related to decisive moments of the match and impose severe fatigue levels on football players, and are often preceded by lower intensity running patterns or walking on the field.
Ricardo Pimenta +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Advanced Exercise and Health ScienceTo investigate the effects of swimming and corn peptide on counteracting obesity of high-fat diet (HFD)-induced mice and uncover the underlying mechanisms through analyzing the compositions and structure of gut flora and corresponding metabolites, an ...
Qiuyue Wu, Ya Liu, Jinxiu Li, Tong Wu
doaj +1 more source