Results 71 to 80 of about 587,830 (281)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The relationship between sports facility accessibility and physical activity among Korean adults
BMC Public Health, 2016 Background The benefits of physical activity on physical and mental health are well known. The accessibility of sports facilities is reported to have considerable association with the amount of physical activity a person participates in.
Sang Ah Lee +6 more
doaj +1 more source
Financing Professional Sports Facilities [PDF]
This paper examines public financing of professional sports facilities with a focus on both early and recent developments in taxpayer subsidization of spectator sports.
Robert A. Baade, Victor A. Matheson
core
Bisnis Olah Raga: Peran Bauran Pemasaran pada Keberhasilan Usaha [PDF]
, 2017 As a big city, Bandung needs sports area and facilities. However, in fact, just a little land available to be utilized. Seeing this potential market, some people who are keen to catch this opportunity are competing to set up the necessary sports ...
Harmon, H. (Harmon) +1 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Spatial Justice and Accessibility: Optimizing Sports Facility Allocation in Tehran
LandThe optimal allocation of sport facilities is crucial for urban management, as it enhances public health and improves citizens’ quality of life. This study proposed a novel decision-making approach for optimizing the allocation of sports facilities in a ...
Rohollah Asgari Gandomani +3 more
doaj +1 more source
International Journal of Behavioral Nutrition and Physical Activity, 2018 Background Income inequalities in sports participation are shaped by a system in which individuals and the environment interact. We developed an agent-based model (ABM) that could represent this system and used it to provide a proof-of-concept of its ...
David J. Blok +2 more
doaj +1 more source
GEOGRAPHY OF A SPORTS METROPOLIS [PDF]
This study analyzes the sports infrastructure of Hamburg, Germany, from the residents’ perspective. Empirical evidence is provided using a micro-level dataset of 1,319 sports facilities, which is merged with highly disaggregated data on population, socio-
Arne FEDDERSEN, Gabriel M. AHLFELDT
core
The Economics of Sportsmanship [PDF]
, 2016 Cheaters never win and winners never cheat. Most children have heard this simple admonition at some point. It is truly unfortunate that it is not true. Sometimes athletes cheat and win, at least for a while.
Smith, Clair
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source