Results 71 to 80 of about 61,738 (285)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The spatial development of sports facilities within the cities: a Central European case study [PDF]
GeoSport for Society, 2014 As a result of the increasing significance of sports which can be observed in the recent decade, researchers in the field of the urban geography have also begun to pay more attention to the spatial location and development of sports facilities within the
Gábor KOZMA
doaj
Управление культурой, 2023 Computer and video games are enumerated as a part of the creative industries in the Creative Industries Development Concept adopted in 2021 in the context of media development and digital content production.
Dmitriy L. Sivovolov +1 more
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Improvement of the Safe Environment of American University Indoors Sports Facilities of Research [PDF]
, 2012 [[abstract]]"The purpose of this study was to explore how to enhance the safe environment in American university indoor sports facilities. A primary research question for this research was:“What are the efforts of enhance the safe environment in ...
王秀瑾;Wang, Hsiu-Chin;陳朝鍵;Chen, Chao-Chien
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Surveys assessing sports services and municipal governance
European Journal of Government and Economics, 2020 This study aims to investigate the social importance of sport in L’Hospitalet de Llobregat. As an instrument for social cohesion and integration, sport has become a very important part of municipal activity.
Júlia Bosch +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Professional Sports Facilities, Franchises and Urban Economic Development [PDF]
Local political and community leaders and the owners of professional sports teams frequently claim that professional sports facilities and franchises are important engines of economic development in urban areas.
Dennis Coates, Brad R. Humphreys
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