Results 61 to 70 of about 6,974 (207)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Strategic Perspective Codification of Iran Martial Arts Federation

Annals of Applied Sport Science, 2019
Background. The current study aimed at codifying the strategic perspective of Iranian federation of martial arts sport. Objectives. The current study aimed at investigating the negative consequences of the use of social networks at the workplace from the
Shahin Soltanpour, Seyed Mohammad Hossein Razavi, Seyed Nasrollah Sajjadi, Habib Honari   +3 more
doaj  

BEDEN EĞİTİMİ VE SPOR YÜKSEKOKULU (BESYO) ÖĞRENCİLERİNİN İLETİŞİM BECERİSİ ALGILARININ BAZI DEĞİŞKENLER AÇISINDAN İNCELENMESİ

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2009
Bu araştırma Beden Eğitimi ve Spor Yüksekokulu’ndaki Beden Eğitimi ve Spor Öğretmenliği, Spor Yöneticiliği, Antrenörlük Eğitimi Bölümleri öğrencilerinin iletişim becerisi algılarının ne olduğunu belirlemek amacıyla yapılmıştır.
Özden Tepeköylü, Mümine Soytürk, Hatice Çamlıyer   +2 more
doaj   +1 more source

Management educativo e sport Education management and sport

, 2016
ABSTRACT The aim of this paper is to highlight how the aspects of the educational and formative approach of an individual, can improve the enterprise management and the respective human resources, and vice versa. It identifies that the objective of such reasoning is an overall social well-being; in fact, by applying an “educational management” model ...
D. Di Palma, MASALA, Daniele, A. Ascione, D. Tafuri   +3 more
openaire   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Analyzing the effective environmental factors in the selection of sports products (Study area: Tehran city) [PDF]

تحقیقات کاربردی علوم جغرافیایی
Green marketing has emerged as a significant area of interest, particularly among sports consumers who express concern regarding environmental issues and demonstrate a willingness to purchase eco-friendly products.
zahra Asgari Gandomani, hamid roodbari, yaghoob mohammadi   +2 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Managing football infrastructure objects after World Cup 2018: foreign experience and Russian perspectives

Управление, 2018
In the article managerial and financial aspects of holding FIFA (фр. Fеdеration Internationale de Football Association) World Cup 2018 in Russia are disclosed.
Sh. M. Ramazanov
doaj   +1 more source