Results 71 to 80 of about 6,974 (207)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Management and legacy of the Brazil 2014 Fifa World Cup during its candidacy bid
Motriz: Revista de Educacao FisicaAim: Sporting mega-event organization requires developing strategies to maximize the chance of success. For the Brazil 2014 Fifa World Cup, it was not different. The action started long before the opening match on 06/12/2014.
Rômulo Meira Reis +3 more
doaj +1 more source
Phenomenology and Sports Management: Explaining the Phenomenological Approach with an Emphasis on Studying Risk-Taking Among Mountaineers [PDF]
Archives in Sport Management and LeadershipPhenomenology, derived from the Greek words phainomenon (“that which appears”) and logos (“the study or revelation of meaning”), is a philosophical and qualitative research approach concerned with understanding lived experience as it is subjectively ...
Rasool Norouzi Seyed Hossini +2 more
doaj +1 more source
Governance and Management in the Business of Sport [PDF]
Symphonya. Emerging Issues in Management, 2004 Sport activities and the environment around them are widely considered as being important examples of the emerging service economy, which cultivates strong ties with both the financial and the industrial sectors. Sports are social economic activities where developments indicate the existence of a dynamic process.
openaire +4 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Acta Universitatis Palackianae Olomucensis. Gymnica, 2010 BACKGROUND: Voluntary work represents 13.5% of the economic strength of Slovenian extra curricular sport (Jurak & Bednarik, 2006). Therefore, managing such a significant source is an important task of Slovenian sports management.
Jakob Bednarik, Gregor Jurak
doaj