Results 61 to 70 of about 2,454,539 (291)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Unveiling the urban sports landscape: Profiling participants, motives, and policy implications.

PLoS ONE
BackgroundThe lack of knowledge regarding urban sports poses pressing challenges for governments and sports organisations to deal with in light of its increasing popularity.
Jef Huyghe, Nathan D'Hoore, Erik Thibaut, Jeroen Scheerder   +3 more
doaj   +1 more source

Empowerment and social inclusion through Para sports: a qualitative study on women with physical impairments in Saudi Arabia

Frontiers in Psychology
BackgroundParticipation in sports represents a potent means of empowerment and social inclusion. Nevertheless, women with physical impairments encounter specific challenges in accessing Para sports.
Majed M. Alhumaid, Yuhanis Adnan, Mohamed A. Said, Maryam A. Alobaid, Selina Khoo   +4 more
doaj   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of sports participation, spontaneous sports, and motivational factors on the physical fitness of university students in Fuzhou

BMC Public Health
Background This study seeks to propose and empirically test a conceptual model that elucidates the complex interrelationships among sports participation, spontaneous sports, sports motivation, lifelong sports, and physical fitness among university ...
Xiangfei Zhu, Jidong Lin, Feng Cai, Yanqing Yan   +3 more
doaj   +1 more source

The effect of sports participation on the social identity of Chinese university students

Frontiers in Psychology
ObjectiveStrengthening youth sports and comprehensively promoting the participation of Chinese university students in sports to enhance their social acceptance are key initiatives for delivering high-quality talent for China’s economic and social ...
Shuyu Ji, Shuwei Chen, Xiannan Yang, Tongshang Liu, Xiaolin Wang   +4 more
doaj   +1 more source

Examining the relationship between sports participation and youth developmental outcomes for socially vulnerable youth

BMC Public Health, 2018
Background Research has shown that sports participation is positively related to youth developmental outcomes, but it is still unknown if sports participation relates to these outcomes among socially vulnerable youth.
Sabina Super, Niels Hermens, Kirsten Verkooijen, Maria Koelen   +3 more
doaj   +1 more source