Results 101 to 110 of about 9,153,567 (241)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gender Differences and Performance Changes in Sprinting and Long Jump Among Young Athletes

Sports
This research aimed to examine the dynamics of changes in sprint and long jump performance and the age of gender divergence in well-trained young athletes specialising in athletics.
Eduard Bezuglov, Evgeniy Achkasov, Timur Vakhidov, Georgiy Malyakin, Elizaveta Kapralova, Vyacheslav Kolesnichenko, Mikhail Vinogradov, Tatiana Zharikova, Anton Emanov   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of Low-Load and Low-Volume Squat Training Combined with Plyometrics During a Full Season on Physical Performance in Young Soccer Players

Sports
The aim of this study was to analyze the effects of a 24-week low-load, low-volume resistance training (RT) program combined with plyometric exercises on the physical performance of U-15 male soccer players.
Felipe Franco-Márquez, Carmen Serrano-Cañadillas, Juan Manuel Yáñez-García, Juan José González-Badillo, David Rodríguez-Rosell   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Kinematic demands of FIFA’s EPTS validation circuit compared to a sport-specific alternative

Scientific Reports
This study compared the kinematic demands of FIFA’s Electronic Performance and Tracking Systems (EPTS) validation circuit with an alternative sport-specific circuit (SSC).
Rafael Luiz Martins Monteiro, Paulo Roberto Pereira Santiago, Patrick Blauberger, Guilherme de Sousa Pinheiro, Tiago Guedes Russomanno, Martin Lames   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The impact of flywheel resistance squat training on lower limb strength in female college basketball players

Frontiers in Physiology
ObjectiveThis study compared the effects of Flywheel Resistance Squat Training (FRST) vs. Traditional Resistance Squat Training (TRST) on lower body strength in female collegiate basketball players.MethodsNineteen participants were randomly assigned to ...
Lin Xie, Wenhao Qu, Jing Dai, Jiamin Xu, Wenfeng Zhang, Jian Sun, Jian Sun, Wenfeng Song, Wenfeng Song, Duanying Li, Duanying Li   +10 more
doaj   +1 more source