Results 51 to 60 of about 1,345,844 (292)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Spot Coffee [PDF]

open access: yes, 1980
SPoT Coffee has been proudly operating in New York State since 1996. The company designs, builds, operates and franchises community-oriented cafés that provide customers with world class service, signature dishes and gourmet coffee roasted in-house. SPoT’
Spot Coffee
core  

Frank and Mary One Spot interview

open access: yes, 1983
28 p. transcript of an interview with Frank and Mary One Spot conducted by Tony Snowsill on July 5, 1983. Tape number IH-156, transcript disc 7.Frank and Mary One Spot give a general account of the movement of the Sarcee Indians ...
One Spot, Frank   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Confocal microscopy [PDF]

open access: yes, 2011
Chapter focusing on confocal microscopy. A confocal microscope is one in which the illumination is confined to a small volume in the specimen, the detection is confined to the same volume and the image is built up by scanning this volume over the ...
Wilson, Tony   +2 more
core   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Real-time laser spot modulation in Laser Powder-Directed Energy Deposition via wobbling: A path to superior 316L stainless steel components

open access: yesJournal of Materials Research and Technology
Achieving high-quality Laser Powder-Directed Energy Deposition (LP-DED) components require the precise tuning of process parameters such as laser power, scanning speed, and laser spot size.
Stefano Felicioni   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Heat conduction and polymer flow in spot/scanning laser-assisted imprinting

open access: yesMechanical Engineering Journal, 2019
Laser-assisted thermal imprinting (LATI) is a promising high-throughput direct replication method for micro- or nanostructured films. In LATI, only the surface of the mold is heated by laser irradiation and the surface of the polymer is heated by heat ...
Keisuke NAGATO   +4 more
doaj   +1 more source

Ultrasmall spot size scanning laser ophthalmoscopy

open access: yesBiomedical Optics Express, 2011
An ultrasmall spot size scanning laser ophthalmoscope has been developed that employs an annular aberration-corrected incident beam to increase the effective numerical aperture of the eye thereby reducing the width of the probing light spot. Parafovea and foveal cone photoreceptor visibility determined from small area retinal image scans are discussed ...
Vohnsen, Brian, Rativa, Diego
openaire   +2 more sources

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