Results 141 to 150 of about 565,621 (377)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Atypical fulminant Rickettsia rickettsii infection (Brazilian spotted fever) presenting as septic shock and Adult Respiratory Distress Syndrome

open access: yesBrazilian Journal of Infectious Diseases
Brazilian spotted fever, caused by Rickettsia rickettsii, has been increasingly reported in Brazil especially in the southeastern states. The severe and fulminant forms of the disease are not unusual but most of the reported fatal cases have shown some ...
Paulo Sérgio Gonçalves da Costa   +3 more
doaj   +1 more source

Epidemiological characteristics of Brazilian spotted fever in Minas Gerais State, Brazil, 2000-2008

open access: yesCadernos de Saúde Pública, 2011
Brazilian spotted fever is the most common rickettsiosis in Brazil, most prevalent in the States of São Paulo and Minas Gerais. The aim of this study was to describe the epidemiological characteristics of Brazilian spotted fever in Minas Gerais from 2000
Frederico Figueiredo Amâncio   +7 more
doaj   +1 more source

“Molecular Docking and Dynamic Studies of Amide Derivatives from Cinnamic Acid with Potential Anti‐Dengue Virus Activity”

open access: yesChemistryOpen, EarlyView.
A library of easily synthesizable CAPE analogs was screened in silico against the dengue virus envelope protein. Compound LQM778 showed stable binding and promising inhibitory potential. This study highlights LQM778 as a candidate for future in vitro validation and structural optimization toward accessible antiviral agents against dengue.
Luis Alfonso Cárdenas‐Granados   +9 more
wiley   +1 more source

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

open access: yesChemistryOpen, EarlyView.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder   +6 more
wiley   +1 more source

Tick-Borne Diseases and Pregnancy: A Narrative Review Evaluating Pregnancy Complications Caused by Tick-Borne Diseases

open access: yesTropical Medicine and Infectious Disease
Ticks are vectors of public health concern because the pathogens they transmit can cause detrimental diseases in humans. Lyme disease, tick-borne relapsing fever, human granulocytic anaplasmosis, Rocky Mountain spotted fever, tick-borne encephalitis ...
Michael W. Curtis, Job E. Lopez
doaj   +1 more source

Tick borne illness in Missouri [PDF]

open access: yes, 2014
Missouri is a hotbed for tick-borne illness given its abundance of rural geography and wildlife, especially deer. The two most frequently encountered ticks in Missouri are the lone star tick, Amblyomma americanum and the American dog tick, Dermacentor ...
Roland, William E.
core  

Wild meat consumption in changing rural landscapes of Indonesian Borneo

open access: yesPeople and Nature, EarlyView.
Abstract Wild meat can play a crucial role in the food system of rural communities residing near tropical forests. Yet, socio‐ecological changes across tropical landscapes are impacting the patterns and sustainability of meat consumption. To understand the prevalence, frequency and drivers of wild meat, domestic meat and fish consumption in this ...
Katie L. Spencer   +12 more
wiley   +1 more source

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