Results 41 to 50 of about 18,754 (257)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing

Emerging Infectious Diseases, 2017
After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R.
Rikki M.A. Graham, Steven Donohue, Jamie McMahon, Amy V. Jennison   +3 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Rocky Mountain spotted fever contracted along a Canadian road trip: A case report

SAGE Open Medical Case Reports
Rocky Mountain spotted fever, a potentially fatal tick-borne disease thought to be confined to specific climates and geographic locations, is expanding its reach due to climate change.
Aliyah King, Alison Spurr, Reetesh Bose
doaj   +1 more source

Rickettsia parkeri in Amblyomma maculatum Ticks, North Carolina, USA, 2009–2010

Emerging Infectious Diseases, 2011
We detected Rickettsia parkeri in 20%−33% of Amblyomma maculatum ticks sampled in North Carolina. Results highlight the high frequencies of R. parkeri–infected ticks in the state with the highest annual incidence of Rocky Mountain spotted fever ...
Andrea S. Varela-Stokes, Christopher D. Paddock, Barry Engber, Marcee Toliver   +3 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Spotted fever rickettsiosis in Coronel Fabriciano, Minas Gerais State

Revista da Sociedade Brasileira de Medicina Tropical, 2003
We report cases of spotted fever rickettsiosis in Coronel Fabriciano Municipality of Minas Gerais State, Brazil. The cases occurred in May and June of 2000.
Galvão Márcio Antônio Moreira, Calic Simone Berger, Chamone Chequer Buffe, Mafra S. Cláudio Lísias, Cesarino Filho Gracco, Olano Juan Pablo, Walker David Hughes   +6 more
doaj  

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Dermacentor occidentalis Ticks and Link to Rickettsia lanei Infections, California, USA

Emerging Infectious Diseases
Rickettsia lanei is a newly recognized spotted fever group rickettsial species that causes severe Rocky Mountain spotted fever–like illness. We used genome sequencing, enabled by hybridization capture-based target enrichment, to establish Dermacentor ...
Will S. Probert, Chantha Kath, Naomi Putirka, Megan E.M. Saunders, Brenda Bermudez, Matthew I. Cazas, Alex Espinosa, Hannah Romo, Jill K. Hacker   +8 more
doaj   +1 more source

Primary isolation of spotted fever group rickettsiae from Amblyomma cooperi collected from Hydrochaeris hydrochaeris in Brazil

Memorias do Instituto Oswaldo Cruz, 1996
This paper reports the first isolation of a spotted fever group rickettsia from an Amblyomma cooperi ixodid collected from a capybara (Hydrochaeris hydrochaeris) in an endemic area of spotted fever in the County of Pedreira, State of São Paulo, Brazil ...
Elba Regina Sampaio de Lemos, Heloísa Helena Barbosa Melles, Sílvia Colombo, Raimundo Diogo Machado, José Rodrigues Coura, Maria Angélica Arpon Guimarães, Selênio R Sanseverino, Aline Moura   +7 more
doaj   +1 more source