Results 71 to 80 of about 19,606 (258)
Epilepsia Open, EarlyView.Abstract Objective To determine whether computational protein‐stability predictions discriminate pathogenic from benign SCN1A missense variants, and to characterize the structural distribution of predicted destabilization among pathogenic variants. Methods On an AlphaFold3‐predicted Nav1.1 structure, FoldX, and Rosetta Cartesian ΔΔG were computed for a
Youngkyu Shim +3 more
wiley +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Mechanisms of immunity to Rickettsia and implications for vaccine development
Revista Colombiana de Ciencias Pecuarias, 2017 Immunity to spotted fever group Rickettsiae following primary infection prevents reinfection as judged by the absence of documented second infections after recovery.
David H. Walker
doaj
Feminist Anthropology, EarlyView.Abstract When I was 12, my family told me a story about their community falling apart and coming together, a time when someone tried putting a nuclear facility in their (our?) hometown. Since we moved when I was too young to remember, the story had little significance until I embarked on a “hometown” ethnographic journey for my dissertation.
Chandler L. Classen
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2005 Brazilian spotted fever (BSF) cases have been increasing in the state of São Paulo but no genomic information about local rickettsia isolated from humans has been well documented.
Elvira Maria Mendes Nascimento +5 more
doaj +1 more source
Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors
FlexMat, EarlyView.This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu +3 more
wiley +1 more source
EPIDEMIOLOGICAL PROFILE OF BRAZILIAN SPOTTED FEVER IN BRAZIL BETWEEN 2018 AND 2024
Brazilian Journal of Infectious DiseasesIntroduction/Objective: Brazilian spotted fever is an infectious disease caused mainly by Rickettsia rickettsii, transmitted by ticks, with Amblyomma spp. as the main vector.
Felipe Piccoli Rostirolla +5 more
doaj +1 more source
Membranous dysmenorrhea and decidual casts: A scoping review
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Background Membranous dysmenorrhea, characterized by the expulsion of intact endometrial tissue rather than gradual dissolution during menstruation, occasionally presents as a decidual cast—a complete triangular mold of the uterine cavity. This poorly understood condition is likely underdiagnosed.
Lovisa Brehmer, Hedvig Engberg
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source