Results 231 to 240 of about 253,751 (300)

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Optical Analysis of Cyclic Voltammetry of Ferrocenemethanol: A Comparative Study of SPR and LSPR. [PDF]

Langmuir
Johnson ZT, Christodoulides JA, Bird LJ, Robitaille M, Raphael MP, Golden JP, Johns P, Trammell SA.   +7 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Room-temperature isopropanol detection using plasmonic optical fiber gas sensor with platinum-doped zinc oxide nanoparticles. [PDF]

iScience
Hou J, Wang Y, Cui X, Wang H, Li C, Ren F, Lu C, Chen Z, Chen Y, Luo J, Li X, Tao R.   +11 more
europepmc   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Gold Nanoparticle-Enhanced Dual-Channel Fiber-Optic Plasmonic Resonance Sensor. [PDF]

Sensors (Basel)
Hua F, Shi H, Chen Q, Xu W, Wang X, Li W.   +5 more
europepmc   +1 more source

Multiaxial Fatigue Behavior of AA6016 and AA6016 to DX54D SPR Joints: Fracture Mechanisms and Data‐Driven Rupp's Model

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT The fatigue and fracture behavior of self‐piercing rivet (SPR) joints between AA6016 aluminum sheets (1–2 mm) and DX54D steel (0.95 mm) was studied under 90°, 45°, and 0° multiaxial loading. Pure shear (90°) loading produced the highest fatigue strength, whereas multiaxial (45°) loading resulted in reduced performance, with pure tension (0 ...
Alan Woo, Amelie Malpot, Behzad Behravesh, Saeid Rezaee, Amirsalar Anousheh, Hamid Jahed   +5 more
wiley   +1 more source

Mango peels-assisted synthesis of carbon quantum dots for potential optical sensing of diazinon. [PDF]

Sci Rep
Asri NAN, Fen YW, Fauzi NIM, Kamaruzzaman NA, Khaidir REM, Hashim HS, Anuar MF, Zailani MAZM, Fadzil ADIM, Basari NNAM, Kamarudin MA, Abdullah H.   +11 more
europepmc   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Quantitative Detection of <i>Salmonella Typhimurium</i> in Ground Chicken Using a Surface Plasmon Resonance (SPR) Biosensor. [PDF]

Biosensors (Basel)
Thapa S, Chen FC.
europepmc   +1 more source