Results 71 to 80 of about 253,751 (300)

Borel Isomorphism of SPR Markov Shifts

open access: yes, 2014
We show that strongly positively recurrent Markov shifts (in particular shifts of finite type) are classified up to Borel conjugacy by their entropy, period and their numbers of periodic ...
Boyle, Mike   +2 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

open access: yesAdvanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang   +16 more
wiley   +1 more source

Comparison of enzyme-linked immunosorbent assay, surface plasmon resonance and biolayer interferometry for screening of deoxynivalenol in wheat and wheat dust [PDF]

open access: yes, 2016
A sample preparation method was developed for the screening of deoxynivalenol (DON) in wheat and wheat dust. Extraction was carried out with water and was successful due to the polar character of DON.
De Saeger, Sarah   +7 more
core   +3 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

open access: yesAdvanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang   +8 more
wiley   +1 more source

Modelling self-piercing riveted joint failures in automotive crash structures [PDF]

open access: yes, 2008
This paper describes a new model and method to predict Self-Piercing Riveted (SPR) joint interlock failures in aluminium sheet at crash speeds using explicit finite element simulation.
Buckley, M.A.   +4 more
core  

Differential Fragment SPR (DF-SPR) for Antimalarial Drug Screening [PDF]

open access: yesBiophysical Journal, 2013
Malaria has been a human health concern for centuries, particularly in tropical and subtropical regions of the world. Nevertheless, our repertoire of medication to treat the disease has been very limited, and emerging resistance of the malaria parasite Plasmodium has further restricted the use of current medications.
Hain, Adelaide U.P., Bosch, Jürgen
openaire   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

Rearrangement operations on unrooted phylogenetic networks

open access: yesTheory and Applications of Graphs, 2019
Rearrangement operations transform a phylogenetic tree into another one and hence induce a metric on the space of phylogenetic trees. Popular operations for unrooted phylogenetic trees are NNI (nearest neighbour interchange), SPR (subtree prune and ...
Remie Janssen, Jonathan Klawitter
doaj   +1 more source

From Physics Model to Results: An Optimizing Framework for Cross-Architecture Code Generation [PDF]

open access: yes, 2013
Starting from a high-level problem description in terms of partial differential equations using abstract tensor notation, the Chemora framework discretizes, optimizes, and generates complete high performance codes for a wide range of compute ...
Blazewicz, Marek   +8 more
core   +4 more sources

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

open access: yesAdvanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou   +6 more
wiley   +1 more source

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