Results 211 to 220 of about 332,610 (361)

Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading

Animal Models and Experimental Medicine, EarlyView.
In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu, Fengguang Yang, Hefang Xiao, Yanni Duan, Xuewen Kang   +4 more
wiley   +1 more source

Hyperglycemia alters the gene and protein expression of CDC42 in small and large intestine of Sprague-Dawley rats. [PDF]

Mol Cell Biochem
Stojanovic M, Mendoza-Mari Y, Rai V, Agrawal DK.   +3 more
europepmc   +1 more source

Antihyperlipidemic Activities of a Chemically Engineered Sulfated Mushroom β-glucan on High Fat Dietary-induced Hyperlipidemia in Sprague-Dawley Rats

, 2014
Yong Hyun Kim, Kook‐Il Han, Mi-Ae Jeon, Seon Gu Hwang, Eui‐Gil Jung, Hyun‐Jung Kwon, Man‐Deuk Han   +6 more
openalex   +2 more sources

Establishment and multifaceted characterization of a graded spinal cord injury model based on graduated impact depth

Animal Models and Experimental Medicine, EarlyView.
We established a graded spinal cord injury (SCI) model based on graduated impact depth, which was subsequently characterized across multiple dimensions, including locomotor function, imaging, histology, and transcriptomic profiles. We further identified transcriptomic changes in graded SCI at different time points postinjury and investigated the ...
Gang Zhou, Yue Hu, Zhimin Li, Shiyuan Han, Yuejia Li, Yongning Li, Jun Gao   +6 more
wiley   +1 more source

Fertility and Early Embryonic Development Toxicity of hzVSF-v13 in Sprague-Dawley Rats. [PDF]

J Appl Toxicol
Jeong JS, Kim SY, Lee J, Lee SJ, Ham O, Kim W, Im WJ, Park S, Ko KC, Kim JC, Kim YB.   +10 more
europepmc   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

[Expression of Concern] Fibrinogen facilitates atherosclerotic formation in Sprague-Dawley rats: A rodent model of atherosclerosis. [PDF]

Exp Ther Med
Zhou B, Pan Y, Yu Q, Zhai Z.
europepmc   +1 more source

Safety evaluations of aqueous stem bark extract of Lophira lanceolata in Sprague dawley rats

, 2010
Etuk Eu, Muhammad Aa
openalex   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Effect of Supplementation with Red Rooibos Tea on Body Composition, Metabolic Outcomes, and Movement in Ovariectomized Sprague-Dawley Rats. [PDF]

Curr Dev Nutr
Feld RS, Ianiero MA, Goncharow MK, Kays DB, Madanat S, MacPherson RE, Roy BD, Ward WE.   +7 more
europepmc   +1 more source