Results 311 to 320 of about 336,467 (360)

Behavioral heterogeneity in Sprague-Dawley rats

Physiology & Behavior, 1992
Because of consistent individual differences in animal behavior, it is often difficult to interpret experimental data. We therefore attempted to rank Sprague Dawley rats by a hierarchical ascendant clustering technique using data from avoidance conditioning and open-field testing (scores of exploratory activity before, during, and after an ...
M, Curé, J P, Rolinat
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Spontaneous Hibernomas in Sprague-Dawley Rats

Toxicologic Pathology, 2009
Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%.
Richard H, Bruner, Meliton N, Novilla, Catherine A, Picut, Jeannie B, Kirkpatrick, Thomas P, O'Neill, Kathryn L, Scully, Wade B, Lawrence, Dawn G, Goodman, Brett H, Saladino, David G, Peters, George A, Parker   +10 more
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Postirradiation Sarcomas in Sprague-Dawley Rats

Radiation Research, 1998
A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in
P T, Tinkey, T M, Lembo, G R, Evans, J H, Cundiff, K N, Gray, R E, Price   +5 more
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Prostate cancer in a Sprague‐Dawley rat

The Prostate, 1985
AbstractAn adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague‐Dawley (S‐D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA‐SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to ...
M, Pollard, P H, Luckert
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Respiration in Sprague-Dawley Rats During Pregnancy

Inhalation Toxicology, 2006
Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
Teresa L, Leavens, Carl U, Parkinson, R Arden, James, Dennis, House, Barbara, Elswick, David C, Dorman   +5 more
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Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats

Drug and Chemical Toxicology, 2004
Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Manoj, Patel, Cherian, Bapu, Harish, Padh, Manish, Nivsarkar   +3 more
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Spontaneous endocrine tumors in Sprague-Dawley rats

Journal of Cancer Research and Clinical Oncology, 1979
Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas ...
H, Suzuki, U, Mohr, G, Kimmerle
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Spontaneous neoplasms in aged sprague-dawley rats

Archives of Toxicology, 1992
Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
M, Chandra, M G, Riley, D E, Johnson
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Polycystic kidney disease in Sprague-Dawley rats

Experimental and Toxicologic Pathology, 2015
Polycystic kidney disease (PKD) is a cystic genetic disorder of the kidneys which is typically associated with cystic bile duct dilatation in the liver in humans, and domestic and laboratory animals. In humans, there are two types of PKD, autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD ...
Ahmed, Shoieb, Norimitsu, Shirai
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