Results 151 to 160 of about 1,625,584 (294)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intervertebral disc puncture predisposes the disc to Cutibacterium acnes infection via hematogenous and contiguous routes: a rat model study. [PDF]

J Orthop Surg Res
Jia Y, Huang S, Li T, Xu B.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Characterization of Plant-Based Milk-Derived "Fujiharu Butter": Comparison With Butter and Butter-Like Substitutes. [PDF]

J Food Sci
Kazama R, Izawa I, Fujiharu K, Misono T, Hoyamatsu Y, Oi N, Tsuno M, Murakami Y, Shono A.   +8 more
europepmc   +1 more source

The fragility of curating a pioneer community: Deep mediatization and the spread of the Quantified Self and Maker movements [PDF]

, 2020
Andreas Hepp
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The deep serratus anterior plane block for intensive care management of rib fractures: a cadaveric study on spread patterns. [PDF]

BMC Anesthesiol
Alparslan V, Yörükoğlu HU, Örs A, Canikoğlu M, Çakır Ö, Cesur S, Aksu C, Çolak T, Kuş A, Çiftçi E.   +9 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Phylogenetic Context of Antibiotic Resistance Provides Insights into the Dynamics of Resistance Emergence and Spread. [PDF]

J Infect Dis
Gontjes KJ, Singh A, Sansom SE, Boyko JD, Smith SA, Lautenbach E, Snitkin E.   +6 more
europepmc   +1 more source

Spread Through Air Spaces (STAS) in Non−Small Cell Lung Carcinoma

, 2021
Daniel Gross, Min‐Shu Hsieh, Yan Li, Joseph Dux, Natasha Rekhtman, David R. Jones, William D. Travis, Prasad S. Adusumilli   +7 more
openalex   +2 more sources