Results 161 to 170 of about 1,625,584 (294)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The potential impact of public health care denial on the transmission dynamics of COVID-19 in South Africa. [PDF]
Sci ProgJuga M, Nyabadza F.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Influence of Particle Shape and Surface Roughness of Fine Aggregates on the Technological Properties of Glass-Fiber-Reinforced Thin-Layer Concrete. [PDF]
Materials (Basel)Zurauskiene R, Kičaitė A, Moceikis R.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Comparison Between Eleven-Bar Cushion and Pillow for Contrast Media Spread in Caudal Block. [PDF]
J Clin MedCho J +9 more
europepmc +1 more source
Determinants of shipping bank loan spreads: An empirical study
, 2017 강병태, 김명희, Kihwan Lee
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Simulating nationwide coupled disease and fear spread in an agent-based model. [PDF]
Sci RepKitson J +7 more
europepmc +1 more source
Rapidly Spreading Optic Pathway Glioma with Intracranial Extension - Case Report
, 2019 Aashish Dhage, B Shukla, Purendra Bhasin
openalex +1 more source