Results 201 to 210 of about 3,568,047 (295)

Quantifying the spatiotemporal dynamics of the first two epidemic waves of SARS-CoV-2 infections in the United States. [PDF]

PLoS Comput Biol
Lopes R, Lan Y, Chitwood MH, Klaassen F, Salomon JA, Menzies NA, Warren JL, Grubaugh ND, Cohen T, Swartwood NA.   +9 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

A Newcastle disease outbreak in backyard and free-range poultry in Slovenia. [PDF]

Front Vet Sci
Žlabravec Z, Slavec B, Dovč A, Hari A, Račnik J, Wernig JM, Giussani E, Palumbo E, Varotto M, Monne I, Krapež U.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A comprehensive analysis of the SARS-CoV-2 omicron variant in Tocantins State, Brazil, and tracing the spread of the XBB.1.18.1 lineage. [PDF]

Braz J Microbiol
Santos MS, de Souza UJB, Cardoso FDP, Galvão JD, Spilki FR, de Almeida Soares CM, Campos FS.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Olfactory decline tracks central-to-peripheral spread of tau pathology in Alzheimer's disease. [PDF]

Alzheimers Dement
Bouchoucha K, Collin L, Coquette C, Colmant L, Boyer E, Huyghe L, Quenon L, Gerard T, Salman Y, Hox V, Kienlen-Campard P, Hanseeuw B, Decottignies A, Huart C.   +13 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Evolution and Spread of Regionally Adapted Newcastle Disease Virus Isolates From Live Bird Markets in Nigeria, 2023-2024. [PDF]

Transbound Emerg Dis
Sajo MU, Lee D, Hakizimana JN, Chengula A, El-Yuguda AD, Lee DH, Misinzo G.   +6 more
europepmc   +1 more source