Results 31 to 40 of about 613,855 (290)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Connector locking device [PDF]
, 1970 Slidable spring-loaded locking device eliminates need for safety wiring. Locking device is placed between the connector plug and connector receptacle.
Rabb, L. W.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshuThis paper proposes a simple passive device with an adjustment mechanism for spring constant and damping coefficient to realize a dynamic vibration absorber (DVA) that can be used for various vibration control target frequencies.
Manaya NAITO +2 more
doaj +1 more source
Cartridge firing device designed for attachment, release and ejection of a satellite [PDF]
, 1977 The device functions were performed by a one-piece unit with resulting performances which were of interest regarding the satellite attachment and the accuracies of the path and velocity during separation and ejection.
Pierron, L.
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
DETERMINATION OF CHARACTERISTICS OF THROTTLING DEVICE FOR PNEUMATIC SPRING
Nauka ta progres transportu, 2018 Purpose. This paper focuses on determination of the dependence of the working medium flow on the capacity of the throttling device, its geometric features and the pressure difference in the pneumatic spring cylinder and in the auxiliary reservoir ...
O. H. Reidemeister, A. V. Laguza
doaj +1 more source
Present Status of SPring-8 Insertion Devices
Journal of Synchrotron Radiation, 1998 According to the general policy, namely, the pursuit of pure radiation without any unreasonable heat load, the construction of various insertion devices has been scheduled at SPring-8. Most of them are of the in-vacuum type, which makes it possible to realize short-period devices, so that the fundamental of undulator radiation may be obtained in the ...
openaire +2 more sources
Sleeved damper limits spring surging [PDF]
, 1968 Damping device limits spring surging in delicate instrumentation subjected to shock loading to tolerable limits. The device consists of a spiral formed plastic member interleaved between the spring coils in the same helix ...
Dean, W. C.
core +1 more source
Synchronization of a double pendulum with moving pivots: a study of the spectrum [PDF]
, 2018 The model we consider consists in a double pendulum set, where the pivot points are free to shift along a horizontal line. Moreover, the two pendula are coupled by means of a spring whose extremities connect two points of each pendulum, at a fixed ...
Talamucci, Federico
core +2 more sources