Results 61 to 70 of about 8,390,922 (295)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Effects of cold-water, contrast-water therapy, and active recovery on blood biomarkers and pain in basketball players

Biomedical Human Kinetics
This study evaluated the effects of active recovery (AR), cold-water immersion (CWI), contrast-water therapy (CWT), and a no-recovery control (CWR) on creatine kinase (CK), myoglobin (Mb), and pain pressure thresholds (PPT) in national-level basketball ...
Janusiak Marcin, González-Fernández Francisco T., Leão César, Smoter Małgorzata, Kisilewicz Aleksandra, Klich Sebastian, Silva Rui Miguel   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Comparative effects of short- and long-distance sprint training on speed, change-of-direction ability, and intermittent aerobic endurance in collegiate basketball players

Frontiers in Physiology
BackgroundThis study compared the effects of short-distance sprint training (SST) and long-distance sprint training (LST), under matched total training volume, on sprint performance, change-of-direction (COD) performance and intermittent aerobic ...
Yang Zhang, Jiayi Wang, Zhihai Wang
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Heart Rate Variability and Perceived Recovery as Predictors of Performance in Athletes Competing in Sprint Events

Sensors
Introduction: This study investigated heart rate variability (HRV) and perceived recovery status (PRS) in relation to sprint performance in competitive athletes involved in sprint events.
Stefan Alecu, Gheorghe Adrian Onea
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Emotional intelligence mediates the relationship between sport type and social anxiety in adolescents

Frontiers in Sports and Active Living
BackgroundAdolescence is a developmental period marked by heightened social anxiety vulnerability. Organized sport may protect mental health, but the psychological mechanisms linking sport type to social anxiety remain unclear.ObjectiveThis study ...
Helder Miguel Fernandes, Helder Miguel Fernandes, Henrique Costa, Pedro Tiago Esteves, Pedro Tiago Esteves, Teresa Fonseca, Teresa Fonseca, Samuel Honório, Samuel Honório, Aristides Miguel Machado-Rodrigues, Aristides Miguel Machado-Rodrigues, Aristides Miguel Machado-Rodrigues   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source