Results 81 to 90 of about 8,390,922 (295)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Indirect Role of Sprint Performance in the Relationship Between Explosive Power and Change-of-Direction Ability in Adolescent Athletes: A Structural Equation Modeling Study

Sports
Background: This study examines the hierarchical determinants of change-of-direction (COD) ability in adolescent athletes to assess whether sprint performance functions as a potential intermediate variable of the relationship between explosive power and ...
Ying-Fang Liu, Huan-Chieh Chen, Tso-Yen Mao   +2 more
doaj   +1 more source

Four Weeks of Power Optimized Sprint Training Improves Sprint Performance in Adolescent Soccer Players.

, 2022
PURPOSE: This study compared the effects of heavy resisted sprint training (RST) versus unresisted sprint training (UST) on sprint performance among adolescent soccer players.
ten Siethoff, Lasse, Kambič, Tim,, Bremec, Domen, Kambič, Tim, Psilander, Niklas,, Bremec, Domen,, ten Siethoff, Lasse,, Derakhti, Mikael, Derakhti, Mikael,, Psilander, Niklas   +9 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Acute effects of resisted and assisted locomotor activation on sprint performance

, 2022
Sprinting speed is one of the most significant motor abilities in team sport games and all sprint, hurdling and jumping events in athletics. Over the years numerous methods and devices have been developed to improve sprinting performance. One of the most
Adam Zajac, Aleksander Matusiński, Adam Maszczyk, Artur Gołas   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sprint Starts and the minimum auditory reaction time [PDF]

, 2007
The simple auditory reaction time is one of the fastest reaction times and is thought to be rarely less than 100 ms. The current false start criterion in a sprint used by the International Association of Athletics Federations is based on this assumed ...
Hibbs, Angela, Abigail. Hibbs (7247708), Pain, Matthew, Matthew Pain (1255611)   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of Weighted Vest Sprint Training on Mid-Acceleration and Reactive Strength in Post-PHV Soccer Players

Sports
Background: This study examined the effects of an individualized weighted vest sprint training program on sprint performance and countermovement jump (CMJ) outcomes in post-peak height velocity (PHV) male youth soccer players while accounting for ...
Nikola Stojanović, Branislav Majkić, Jadranka Vlašić, Valentin Barišić, Damir Pekas   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source