Results 71 to 80 of about 85,714 (306)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Physiological correlates of performance in international-standard squash players [PDF]
, 2009 Tactical, technical and fitness factors are important for success in elite squash. While tactical and endurance fitness aspects have been explored, altered demands that have resulted from rule changes and absence of specific tests of high-intensity ...
Cooke, Matthew +5 more
core
Asymmetry During Maximal Sprint Performance in 11- to 16-Year-Old Boys [PDF]
, 2016 Purpose: The aim of this study was to examine the influence of age and maturation upon magnitude of asymmetry in the force, stiffness and the spatiotemporal determinants of maximal sprint speed in a large cohort of boys.
Cronin, John +4 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Applied SciencesThe recognition of high-speed demands in football has led elite academies to prioritize acceleration capabilities for player selection and promotion, particularly given their fundamental role in the motor skills of professional players and their impact ...
Adrián Castaño-Zambudio +2 more
doaj +1 more source
Frontiers in Sports and Active Living, 2021 Improving performances in sprinting requires feedback on sprint parameters such as step length and step time. However, these parameters from the top speed interval (TSI) are difficult to collect in a competition setting.
Thomas Seidl +3 more
doaj +1 more source
The Application of Postactivation Potentiation Methods to Improve Sprint Speed [PDF]
Strength & Conditioning Journal, 2017 ABSTRACTTHIS ARTICLE EXAMINES THE APPLICATION OF A VARIETY OF MODALITIES TO ELICIT A POSTACTIVATION POTENTIATION (PAP) RESPONSE IN SPRINTING. WE PRESENT THE EXISTING LITERATURE ON THE ACUTE EFFECTS OF BACK SQUATS, POWER CLEANS, PLYOMETRICS, AND SLED PULLING ON SPRINT DISTANCES RANGING FROM 5 TO 50 M.
Healy, Robin, Comyns, Thomas M.
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Impact of Nordic hamstring breaking point angle on football player performance [PDF]
PeerJBackground Football demands both aerobic and anaerobic capacities due to its dynamic movements, which include jumps, directional changes, ball control, and sprints.
Murat Koç +11 more
doaj +2 more sources