Results 141 to 150 of about 230,800 (389)

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

open access: yesAdvanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li   +19 more
wiley   +1 more source

Protective Effect of Selenium‐Enriched Red Radish Sprouts on Carbon Tetrachloride‐Induced Liver Injury in Mice [PDF]

open access: bronze, 2019
Li Jia   +9 more
openalex   +1 more source

Quasi‐Bound States in the Continuum on the Bloch‐Surface‐Wave Platform for Sensing With Simultaneous High Q‐Factor and High Sensitivity

open access: yesAdvanced Optical Materials, EarlyView.
Quasi‐bound states in the continuum on the Bloch surface wave platform are demonstrated, exhibiting high Q‐factors due to strongly suppressed radiative losses and high sensitivity arising from the large evanescent field inherent to the surface wave. The resonance shows clear shifts after each surface molecular functionalization step, highlighting its ...
Bo‐Wei Lin   +6 more
wiley   +1 more source

Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats

open access: yesJournal of Neuroscience, 1985
In the rat hippocampal formation, degeneration of CA4-derived afferent fibers provokes the growth of mossy fiber collaterals into the fascia dentata. These aberrant fibers subsequently form granule cell-granule cell synapses.
D. Tauck, J. Nadler
semanticscholar   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

open access: yesAdvanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu   +15 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Respirometer development program and gravity and neurohypophyseal secretory activity Final technical report [PDF]

open access: yes
Microrespirometers to measure oxygen consumption of sprouting potato plugs, and gravitational effects on hypothalamo-hypophyseal system of ...

core   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

open access: yesAdvanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun   +15 more
wiley   +1 more source

Effects of germination time on the antioxidant properties of edible seeds

open access: yesCyTA - Journal of Food, 2019
The aim of this study was to determine the level of antioxidants in the seeds of wheat, lentil, pea, radish, broccoli, alfalfa, sunflower and amaranth germinated for 24, 72 and 120 hours.
Živilė Tarasevičienė   +5 more
doaj   +1 more source

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