Results 221 to 230 of about 155,703 (309)

Decellularized Dermis ECM-Based Melanoma-on-a-Chip Model with Integrated Lymphatic and Vascular Networks for High-Throughput Drug Testing. [PDF]

ACS Appl Bio Mater
Vázquez-Aristizabal P, Arriola-Alvarez I, Henriksen-Lacey M, Alonso-Martin S, van den Broek L, Liz-Marzán LM, Izeta A.   +6 more
europepmc   +1 more source

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, EarlyView.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis. [PDF]

Adv Sci (Weinh)
Kim B, Lee HK, Azam Z, Choi JU, Wahab R, Lee NK, Ko YG, Choi SY, Lee SR, Shim WS, Kim T, Kim IS, Alam F, Kim SY, Kim SW, Byun Y, Al-Hilal TA.   +16 more
europepmc   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source

APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs. [PDF]

Fluids Barriers CNS
Wu YC, Lehtonen Š, Kauppinen R, Dhungana H, Koistinaho J, Rõlova T.   +5 more
europepmc   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source

Multi-omics analysis reveals metabolic diversity underlying endothelial cell functions. [PDF]

Life Sci Alliance
Durot S, Doubleday PF, Schulla L, Sabine A, Petrova TV, Zamboni N.   +5 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Calcineurin-NFAT-DSCR1.4 signaling as druggable axis in Gαq-R183Q-driven capillary malformations. [PDF]

Angiogenesis
Xu T, Janssen V, Reinhard NR, Sobrevals-Alcaraz P, van Es RM, de Haan A, de Swart J, Wehrens M, de Kraker H, Wolkerstorfer A, van der Horst CMAM, Vos HR, Huveneers S.   +12 more
europepmc   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source