Results 81 to 90 of about 226,094 (387)

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat, Mehmed B. Bayram, Morgan Paine, Janelle Carnahan, Jian Zhong, Xiaofei Guan, Guang H. Yue, Soha Saleh, Gail F. Forrest   +8 more
wiley   +1 more source

Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]

, 2018
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core  

Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord [PDF]

, 2016
To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor
Balle, Eric, Blackmore, Murray G., Hoeynck, Brian, Jayaprakash, Naveen, Kramer, Audra A., Krueger, Nicholas, Wang, Zimei, Wheeler, Daniel S., Wheeler, Robert A.   +8 more
core   +2 more sources

MEF2 transcription factors are key regulators of sprouting angiogenesis

Genes & Development, 2016
In this study, Saccilotto et al. investigated the molecular connection between proangiogenic signals and downstream gene expression during angiogenesis.
N. Sacilotto, Kira M. Chouliaras, Leonid Nikitenko, Yao Wei Lu, Martin Fritzsche, Marsha D. Wallace, S. Nornes, F. García-Moreno, S. Payne, E. Bridges, Ke Liu, D. Biggs, I. Ratnayaka, Shane P. Herbert, Z. Molnár, A. Harris, B. Davies, G. Bond, George Bou-Gharios, J. Schwarz, S. De Val   +20 more
semanticscholar   +1 more source

Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis [PDF]

BMC Systems Biology, 2015
BackgroundDuring angiogenesis, the formation of new blood vessels from existing ones, endothelial cells differentiate into tip and stalk cells, after which one tip cell leads the sprout. More recently, this picture has changed.
Sonja E. M. Boas, Roeland M. H. Merks
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Stem girdling evidences a trade-off between cambial activity and sprouting and dramatically reduces plant transpiration due to feedback inhibition of photosynthesis and hormone signaling

Frontiers in Plant Science, 2015
The photosynthesis source-sink relationship in young Pinus canariensis seedlings was modified by stem girdling to investigate sprouting and cambial activity, feedback inhibition of photosynthesis, and stem and root hydraulic capacity.
Rosana eLópez, Ricard eBrossa, Pilar ePita   +2 more
doaj   +1 more source

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Nature Communications, 2015
Sprouting angiogenesis drives blood vessel growth in healthy and diseased tissues. Vegf and Dll4/Notch signalling cooperate in a negative feedback loop that specifies endothelial tip and stalk cells to ensure adequate vessel branching and function ...
Irene M. Aspalter, E. Gordon, Alexandre Dubrac, Anan Ragab, Jarek Narloch, Pedro Vizán, Ilse Geudens, Russell T Collins, C. Franco, C. Abrahams, G. Thurston, M. Fruttiger, I. Rosewell, A. Eichmann, H. Gerhardt   +14 more
semanticscholar   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

A neuroanatomical correlate of sensorimotor recovery in response to repeated vaginocervical stimulation in rats.

Frontiers in Physiology, 2012
Gentle probing against the cervix via the vagina (VCS) increases tail flick latency (TFL) to radiant heat; greater force totally abolishes the tail flick response and other withdrawal responses.
Barry R Komisaruk, Dina R Conde
doaj   +1 more source