Results 91 to 100 of about 146,062 (286)

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, EarlyView.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Thermochronologic Constraints on the Extensional History of the Ibex Hills, Southeastern Black Mountains, Death Valley, California

Geological Journal, EarlyView.
A. Modeled T‐t paths for samples in the northern Ibex Hills, showing steady cooling throughout much of the Cenozoic, until rapid Miocene cooling. B. Weighted mean paths for each sample in this study. Note that all show a rapid cooling event at or just after 10 Ma, which is interpreted to represent exhumation as a result of regional extenstion ...
Zachariah D. Fleming
wiley   +1 more source

Unintended Consequences of Life‐Saving Pharmaceutical Innovations: How HAART Led to the Resurgence of Syphilis

Health Economics, EarlyView.
ABSTRACT Syphilis, a sexually transmitted infection that can lead to serious health complications, was almost eliminated in the United States by 2000. But since then, its incidence began to increase, recently reaching a 60‐year peak. We suggest that the introduction of the highly active antiretroviral therapy (HAART) drug regimen, which transformed HIV
David Beheshti, Scott Cunningham, Nir Eilam   +2 more
wiley   +1 more source

Does high-intensity exercise better improve ambulation in the population with chronic stroke, as compared to standard care?: A Systematic Review of the Literature [PDF]

, 2016
Purpose: To assess the effectiveness of high-intensity exercise on the improvement of gait deficits in survivors of chronic stroke as compared to standard care.https://jdc.jefferson.edu/dptcapstones/1006/thumbnail ...
Caruso, SPT, Caitlin, Comstock, SPT, Courtney, McKenna, SPT, Ashley, Nixon, SPT, Samantha, Tyrell, PT, PhD, NCS, Christine M., Wonneberger, SPT, Ashley   +5 more
core   +1 more source

RAMANUJAN’S SPT-CRANK FOR MARKED OVERPARTITIONS

International Journal of Research -GRANTHAALAYAH, 2015
In 1916, Ramanujan’s showed the spt-crank for marked overpartitions. The corresponding special functions ,  and are found in Ramanujan’s notebooks, part 111. In 2009, Bingmann, Lovejoy and Osburn defined the generating functions for , and . In 2012, Andrews, Garvan, and Liang  defined the  in terms of partition pairs.
Bhattacharjee, Nil Ratan, Sabuj Das
openaire   +2 more sources

Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili, Paolo Bossi, Luca Lalli, Lisa Francesca Linda Licitra, Marta Maddalo, Almalina Bacigalupo, Liliana Belgioia, Jon Cacicedo, Nadia Facchinetti, Almudena Garcia Castano, Marc Oliva, Pierluigi Bonomo, Giuseppe Sanguineti, Pierfrancesco Franco, Athanassios Argiris, Amanda Psyrri, Ester Orlandi   +16 more
wiley   +1 more source

Improved bearing resistance of soil foundations of buildings with injectable polyurethane composites

MATEC Web of Conferences, 2018
The article deals with the analysis of SPT® polyurethane materials and maintenance technologies based on them, and an analytical review of literature on the topic.
Miroshnichenko Sergii, Plugin Dmytro, Kalinin Oleg, Zvierieva Alina, Reznichenko Ivan   +4 more
doaj   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Çukurca İlçesinin Yerleşime Uygunluk Açısından Değerlendirilmesi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Bu çalışmada, Çukurca ilçesinin yerleşimi için uygun, önlemli ve uygun olmayan alanların sınırlarının belirlenmesi amaç edinilmiştir. Bu amaca yönelik olarak, arazi çalışmaları kapsamında jeolojik birimlerin litolojik sınırları çizilmiş, tektonik hatlar ...
Adil Özdemir, Ali Ateş, Burak Yeşil
doaj  

Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae[S]

Journal of Lipid Research, 2018
Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here, we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT.
Jihui Ren, Justin Snider, Michael V. Airola, Aaron Zhong, Nadia A. Rana, Lina M. Obeid, Yusuf A. Hannun   +6 more
doaj   +1 more source