Results 61 to 70 of about 146,062 (286)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Correlations of Strength and Elastic Modulus of Cohesive Soil with SPT in Bakrajo Region-Kurdistan of Iraq

Sulaimani Journal for Engineering Sciences
Reasonably estimating the uniaxial compressive strength (UCS) and elastic modulus (E) of cohesive soil is crucial in the routine design of structures built on such soils.
Kamal Ahmad Rashed
doaj   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Exergoeconomic and Thermodynamic Analyses of Solar Power Tower Based Novel Combined Helium Brayton Cycle‐Transcritical CO2 Cycle for Carbon Free Power Generation

Global Challenges, 2023
In the present study, a novel combined power cycle for solar power tower (SPT) system consisting of helium Brayton cycle (HBC) and transcritical CO2 (TCO2) for waste heat recovery is being studied for carbon‐free generation.
Yunis Khan, Deepak Singh, Hakan Caliskan, Hiki Hong   +3 more
doaj   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Improved correlation of soil modulus with SPT N values

Open Engineering
Determining soil “E” (modulus of deformation) value has been a persistent challenge in geotechnical engineering. Existing correlations between “E” and SPT (standard penetration test) “N” values for granular soils yield a notably broad spectrum of “E ...
Wagh Jaydeep Dinkar, Bambole Abhay Namdeorao   +1 more
doaj   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

The spt-function of Andrews

, 2017
57 pages, 6 figures. An early version has been published in Surveys in Combinatorics 2017, A. Claesson, M. Dukes, S. Kitaev, D. Manlove and K. Meeks, Eds., Cambridge University Press, Cambridge, 2017, pp.
openaire   +5 more sources

Lessons for higher education institutions from the establishment of the Schools Partnership Trust in Leeds (Garforth) and its future development [PDF]

, 2010
"This report identifies strengths and challenges for the Garforth School Partnership Trust (SPT) in Leeds of having Leeds Trinity University College as the Higher Education (HE) external partner and trustee related to governance, strategic planning ...

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