Results 161 to 170 of about 353,966 (351)

Diagnostic management and outcomes of pulmonary tuberculosis suspects admitted to a central hospital in Malawi [PDF]

, 2012
Edginton, M E, Gawa, L G, Harries, A D, Joshua, M, Reid, T, Van Lettow, M   +5 more
core   +2 more sources

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia.

New England Journal of Medicine, 2009
Parameswaran Nair, M. Pizzichini, M. Kjarsgaard, M. Inman, A. Efthimiadis, E. Pizzichini, F. Hargreave, P. O'Byrne   +7 more
semanticscholar   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Validation of Digital Cytology for Primary Diagnosis Across a Range of Specimen Types

Cytopathology, EarlyView.
This single‐centre validation study demonstrated strong diagnostic concordance between high‐resolution whole‐slide imaging and traditional light microscopy across diverse cytology specimen types. Even with limited prior experience, pathologists found digital cytology feasible and acceptable for diagnostic use.
Talisa Mistry, Harriet Hunter, Dahmane Oukrif, Sabine Pomplun, Reena Khiroya, Mary Falzon, Tanya Alan, Manuel Rodriguez‐Justo, Adam P. Levine   +8 more
wiley   +1 more source

Sputum transcriptomics reveal upregulation of IL‐1 receptor family members in patients with severe asthma

Journal of Allergy and Clinical Immunology, 2017
C. Rossios, S. Pavlidis, U. Hoda, C. Kuo, C. Wiegman, K. Russell, Kai Sun, M. Loza, F. Baribaud, A. Durham, O. Ojo, R. Lutter, A. Rowe, A. Bansal, C. Auffray, A. Sousa, J. Corfield, R. Djukanović, Yike Guo, P. Sterk, K. Chung, I. Adcock   +21 more
semanticscholar   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, EarlyView.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Hierarchical analysis of unsuccessful tuberculosis treatment among people living with HIV in Brazil using nationwide surveillance data

HIV Medicine, EarlyView.
Abstract Introduction People with tuberculosis‐HIV coinfection face multiple barriers to effective treatment, including social vulnerability, stigma and limited access to healthcare. This study examined factors associated with loss to follow‐up and death among individuals with tuberculosis‐HIV in Brazil.
Lucas Vinícius de Lima, Gabriel Pavinati, Francisco Beraldi‐Magalhães, Rubia Laine de Paula Andrade‐Gonçalves, Aline Aparecida Monroe, Marcela Demitto Furtado, Rosana Rosseto de Oliveira, Daniele Maria Pelissari, Kleydson Bonfim Andrade Alves, Gabriela Tavares Magnabosco   +9 more
wiley   +1 more source

THE EFFICIENCY OF MOLECULAR AND CONVENTIONAL METHODS IN DETECTION OF CANDIDA ALBICANS ISOLATED FROM IMMUNOCOMMPROMSED PATIENTS WITH PULMONARY SYMPTOMS

The Iraqi Journal of Medical Sciences, 2017
Background: Candida albicans (C. albicans) has emerged as a potentially pathogenic fungus rather than benefit mucosal commensal in patients with pulmonary diseases. Although respiratory candidiasis secondary to pulmonary tuberculosis has been reported in
Azhar A.F. Al-Attraqchi, Marwa A. Hadab, Jabbar S. Hassan, Haider N. Dawood   +3 more
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