Results 141 to 150 of about 805,583 (361)
Advanced Science, EarlyView.Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li +11 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
JEADV Clinical PracticeBackground Black patients often present with advanced skin cancer with worse outcomes compared to White patients. Underrepresentation of Black individuals in US basal cell carcinoma and cutaneous squamous cell carcinoma clinical trials may exacerbate ...
Mara Hartoyo +3 more
doaj +1 more source
Paradigma da disseminação linfática no carcinoma espinocelular da base da língua
Revista do Colégio Brasileiro de CirurgiõesOBJETIVO: O carcinoma espinocelular CEC da base da língua tem um comportamento agressivo, disseminando-se precocemente para o pescoço uni ou bilateralmente.
Francisco S. Amorim Filho +4 more
doaj +1 more source
Advanced Science, EarlyView.A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li +12 more
wiley +1 more source
Eyelid squamous cell carcinoma in xeroderma pigmentosa: A therapeutic challenge
, 1970 A Kaur, P Agarawal, V Jaiswal
openalex +2 more sources
Role of Interleukin-6 Gene Variants in the Development of Oral Squamous Cell Carcinoma
, 2022 özge gümüşay
openalex +1 more source
Advanced Science, EarlyView.This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui +9 more
wiley +1 more source
Primary Squamous Cell Carcinoma of the Gallbladder: Case Report
Clinical Case ReportsPure gallbladder squamous cell carcinoma is rare. Adenocarcinoma is the foremost malignant pathology of gallbladder cancer. Simultaneously, squamous cell carcinoma accounts for only 1% of malignant gallbladder tumors. They are often advanced at diagnosis
Sahar Dashti +4 more
doaj +1 more source