Results 21 to 30 of about 141,551 (313)

Cetuximab in squamous cell head and neck carcinomas

Annals of Oncology, 2007
The epidermal growth factor receptor (EGFR) antagonist, cetuximab, has recently been shown to enhance the effects of radiotherapy, and reports to date indicate that this effect occurs without any change in the pattern and severity of toxicity usually associated with head and neck radiation and/or chemotherapy (CT) administration.
GEBBIA, Vittorio, GIULIANI G, VALORI VM, AGUELI R, COLUCCI G, MAIELLO E.   +5 more
openaire   +3 more sources

PKM2 Modulation in Head and Neck Squamous Cell Carcinoma [PDF]

International Journal of Molecular Sciences, 2022
The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational modifications regulate its activity. Head and neck squamous cell carcinoma (HNSCC) is a common disease with
Verena Boschert, Jonas Teusch, Urs D. A. Müller-Richter, Roman C. Brands, Stefan Hartmann   +4 more
openaire   +3 more sources

CD44s and CD44v6 Expression in Head and Neck Epithelia [PDF]

, 2008
Background: CD44 splice variants are long-known as being associated with cell transformation. Recently, the standard form of CD44 (CD44s) was shown to be part of the signature of cancer stem cells (CSCs) in colon, breast, and in head and neck squamous ...
Olivier Gires, Mack, B., Gires Olivier, Mack, Brigitte, Brigitte Mack, Gires, Olivier, Mack Brigitte, Gires, O.   +7 more
core   +1 more source

Circulating tumor cells in head and neck cancer: A review

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2016
Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures ...
Kyle P. McMullen, Jeffrey J. Chalmers, Jas C. Lang, Pawan Kumar, Kris R. Jatana   +4 more
doaj   +1 more source

Clinical Controversy Surrounding the Differential Diagnosis of Branchiogenic Carcinoma

Case Reports in Otolaryngology, 2022
Clinical evaluation, differential diagnosis, and management of a neck mass constitute commonly encountered problems for the head and neck surgeon. An asymptomatic neck mass in adults may be the only clinical sign of head and neck cancer.
Alexander Karatzanis, Kleanthi Mylopotamitaki, Eleni Lagoudaki, Emmanuel Prokopakis, Sofia Agelaki   +4 more
doaj   +1 more source

Evaluation of epigenetic inactivation of vascular endothelial growth factor receptors in head and neck squamous cell carcinoma

Tumor Biology, 2017
The aim of this study was to determine the methylation status of the genes encoding the vascular endothelial growth factor receptors and to evaluate the usefulness of VEGFR methylation as a prognostic indicator in head and neck squamous cell carcinoma ...
Yuki Misawa, Kiyoshi Misawa, Hideya Kawasaki, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Shiori Endo, Masato Mima, Takeharu Kanazawa, Toshihide Iwashita, Hiroyuki Mineta   +10 more
doaj   +1 more source

Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck [PDF]

, 2006
Background The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness.
Solbach, Christine, Peters Silke, Eckerdt, Frank, Peters, Silke, Knecht, Rainald, Roller, Marc, Roller Marc, Eckerdt Frank, Solbach Christine, Knecht Rainald   +9 more
core   +1 more source

LIHNCS - Lugol's iodine in head and neck cancer surgery : a multicentre, randomised controlled trial assessing the effectiveness of Lugol’s iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma : study protocol for a randomised controlled trial [PDF]

, 2013
Background: Oral cavity and oropharynx cancer are increasing in incidence worldwide but survival outcomes have not significantly improved over the last three decades. The presence of dysplasia or carcinoma in situ at surgical margins following resection
McMahon, Jeremy, Mehanna, Hisham M., McConkey, Christopher C., Hisham Mehanna, Sutton, David N., Dunn, Janet, Cymerman, James A, McCaul, James A, Sutton, David N, Shaw, Richard, James A McCaul, Dunn, Janet A., McCaul, James A., Jeremy McMahon, David N Sutton, Cymerman, James A., Hislop, Stuart, McConkey, Chris, James A Cymerman, Stuart Hislop, Richard Shaw, Mehanna, Hisham; id_orcid, Chris McConkey, Janet Dunn   +23 more
core   +1 more source

Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression

Tumor Biology, 2017
Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development.
Jianfeng Dong, Lijun Cheng, Minchao Zhao, Xiangfeng Pan, Zhiqiang Feng, Dawei Wang   +5 more
doaj   +1 more source

A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma

Frontiers in Genetics, 2023
Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a ...
Yizhou Yang, Yizhou Yang, Yizhou Yang, Zeman Cai, Kaichun Huang, Mei Li, Xiao Wang, Xiao Wang, Xiao Wang, Yinbing Lin, Yinbing Lin, Yinbing Lin, Sijie Chen, Sijie Chen, Sijie Chen, Zhining Yang, Zhining Yang, Zhixiong Lin, Zhixiong Lin, Zhixiong Lin   +19 more
doaj   +1 more source