Results 21 to 30 of about 31,301 (241)
PKM2 Modulation in Head and Neck Squamous Cell Carcinoma [PDF]
International Journal of Molecular Sciences, 2022 The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational modifications regulate its activity. Head and neck squamous cell carcinoma (HNSCC) is a common disease with
Verena Boschert +4 more
openaire +3 more sources
CD44s and CD44v6 Expression in Head and Neck Epithelia [PDF]
, 2008 Background: CD44 splice variants are long-known as being associated with cell transformation. Recently, the standard form of CD44 (CD44s) was shown to be part of the signature of cancer stem cells (CSCs) in colon, breast, and in head and neck squamous ...
Olivier Gires +7 more
core +2 more sources
Clinical Controversy Surrounding the Differential Diagnosis of Branchiogenic Carcinoma
Case Reports in Otolaryngology, 2022 Clinical evaluation, differential diagnosis, and management of a neck mass constitute commonly encountered problems for the head and neck surgeon. An asymptomatic neck mass in adults may be the only clinical sign of head and neck cancer.
Alexander Karatzanis +4 more
doaj +1 more source
Exosomes in Head and Neck Squamous Cell Carcinoma [PDF]
Frontiers in Oncology, 2019 Exosomes are small membranous vesicles that contain proteins, lipids, genetic material, and metabolites with abundant information from parental cells. Exosomes carry and deliver bioactive contents that can reprogram the functions of recipient cells and modulate the tumor microenvironment to induce pathological events through cell-to-cell communication ...
Cheng Xiao +5 more
openaire +3 more sources
Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck [PDF]
, 2008 Introduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them ...
Romano, Carmela
core +1 more source
Tumor Biology, 2017 The aim of this study was to determine the methylation status of the genes encoding the vascular endothelial growth factor receptors and to evaluate the usefulness of VEGFR methylation as a prognostic indicator in head and neck squamous cell carcinoma ...
Yuki Misawa +10 more
doaj +1 more source
Hypoxia in Head and Neck Squamous Cell Carcinoma [PDF]
ISRN Otolaryngology, 2012 Hypoxia is a common feature in most of the solid tumors including head and neck squamous cell carcinoma (HNSCC). Hypoxia reflects the imbalance between oxygen consumption by the rapidly proliferating cancer cells and the insufficient oxygen delivery due to poor vascularization and blood supply.
John Zenghong Li +4 more
openaire +2 more sources
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck [PDF]
, 2006 Background The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness.
Solbach, Christine +9 more
core +1 more source
The role of FOXM1 in oral squamous cell carcinoma [PDF]
, 2010 PhDFOXM1 transcription factor regulates the expression of a multitude of genes, which are important for cell proliferation, mitosis, and differentiation.
Gemenetzidis, Emilios
core +4 more sources
Tumor Biology, 2017 Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development.
Jianfeng Dong +5 more
doaj +1 more source