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Nature Reviews Cancer, 2004
The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer ...
T. Yeatman
semanticscholar +4 more sources
The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer ...
T. Yeatman
semanticscholar +4 more sources
Src proteins/src genes: from sponges to mammals
Gene, 2004The genome of marine sponge Suberites domuncula, a member of the most ancient and most simple metazoan phylum Porifera, encodes at least five genes for Src-type proteins, more than, i.e., Caenorhabditis elegans or Drosophila melanogaster (two in each). Three proteins, SRC1SD, SRC2SD and SRC3SD, were fully characterized.
Vladislav A. Grebenjuk+3 more
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Cellular functions regulated by Src family kinases.
Annual Review of Cell and Developmental Biology, 1997Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and participate in signaling pathways that control a diverse spectrum of receptor-induced biological activities. While several of these
Sheila M. Thomas, J. Brugge
semanticscholar +1 more source
Src Inhibitors and Angiogenesis
Current Pharmaceutical Design, 2007Angiogenesis is a tightly regulated process that leads to the formation of new blood vessels in limited physiological conditions, and can also occur under pathological situations as retinopathies, arthritis, endometriosis and cancer. Enhanced angiogenesis is present in tumors that need new blood capillaries to grow, remove metabolic waste and transport
SCHENONE S+2 more
openaire +6 more sources