Results 351 to 360 of about 512,141 (378)
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Frontiers in Bioscience, 2003
The signaling machinery in cells is a complex, multi-factorial network of cross-talking proteins that enables dynamic communication between upstream causal factors and downstream effectors. Non-receptor tyrosine kinases, including Src, are the intermediates of information transfer, controlling pathways as diverse as cell growth, migration, death, and ...
Scott K Shore, Salvatore V Russello
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The signaling machinery in cells is a complex, multi-factorial network of cross-talking proteins that enables dynamic communication between upstream causal factors and downstream effectors. Non-receptor tyrosine kinases, including Src, are the intermediates of information transfer, controlling pathways as diverse as cell growth, migration, death, and ...
Scott K Shore, Salvatore V Russello
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Nature Reviews Cancer, 2012 Cancer cells target active SRC for autophagy when SRC signalling is deregulated through the loss of focal adhesion kinase.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Science, 1999The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by many receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) requires the activation of Src family tyrosine kinases.
L. Luttrell +11 more
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Fuel, 1981
Abstract The ageing characteristics of a 30 70 (wt%) blend of SRC-I and SRC-II and of a SRC-II middle distillate (boiling-point range 450–565K), have been studied. Viscometric, ultimate analysis, solvent separation, gel permeation chromatography, and 600-MHz n.m.r. measurements have been used to monitor the ageing properties of the SRC liquids
N. C. Li +3 more
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Abstract The ageing characteristics of a 30 70 (wt%) blend of SRC-I and SRC-II and of a SRC-II middle distillate (boiling-point range 450–565K), have been studied. Viscometric, ultimate analysis, solvent separation, gel permeation chromatography, and 600-MHz n.m.r. measurements have been used to monitor the ageing properties of the SRC liquids
N. C. Li +3 more
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Journal of Medicinal Chemistry, 2004
A series of substituted 2-(aminopyridyl)- and 2-(aminopyrimidinyl)thiazole-5-carboxamides was identified as potent Src/Abl kinase inhibitors with excellent antiproliferative activity against hematological and solid tumor cell lines.
L. Lombardo +26 more
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A series of substituted 2-(aminopyridyl)- and 2-(aminopyrimidinyl)thiazole-5-carboxamides was identified as potent Src/Abl kinase inhibitors with excellent antiproliferative activity against hematological and solid tumor cell lines.
L. Lombardo +26 more
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Targeting SRC kinase (SRC) in melanoma cells.
Journal of Clinical Oncology, 20108584 Background: The SRC family of tyrosine kinases have been implicated in melanoma progression.
Alex J Eustace +8 more
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Nature Reviews Molecular Cell Biology, 2001
The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome.
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The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome.
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Nature Cardiovascular Research, 2022
Regulation of the endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in a number of physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation , the critical role of YES in this process, and the vascular leak.
Michael Simons, Derek Toomre
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Regulation of the endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in a number of physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation , the critical role of YES in this process, and the vascular leak.
Michael Simons, Derek Toomre
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Nature, 1994
The activity of the c-Src protein is increased during cell-cycle stage G1 in fibroblasts stimulated with certain growth factors, and at the G2/M transition, but little is known about Src substrates in these circumstances. In contrast, cells transformed with activated Src contain many tyrosine-phosphorylated proteins.
Sara A. Courtneidge +3 more
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The activity of the c-Src protein is increased during cell-cycle stage G1 in fibroblasts stimulated with certain growth factors, and at the G2/M transition, but little is known about Src substrates in these circumstances. In contrast, cells transformed with activated Src contain many tyrosine-phosphorylated proteins.
Sara A. Courtneidge +3 more
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Evolution of oncogenes: From c-src to v-src [PDF]
Nature, 1983 IN a recent issue of Nature, Jean Wang discussed the differences between the cellular and viral versions of the abl oncogene1. This week John Wyke reports some recent explorations of two versions of v-src and its cellular homologue.
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