Results 51 to 60 of about 216,421 (319)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cross‐cultural adaptation and measurement properties of the Persian version of the modified Cincinnati knee rating system

Journal of Experimental Orthopaedics
Purpose To validate and assess the cross‐sectional adaptation of the modified Cincinnati knee rating system (MCRKS) Persian translation. Methods To assess test‐pretest reliability, 102 participants were asked to fill out the MCRKS (Per) scale after ...
Nasim Eshraghi, Peyman Mirghaderi, Reza Omid, Mohamad Sajadi, Amirreza Pashapour‐Yeganeh, S. M. Javad Mortazavi   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Raman solitons in transient SRS

, 2000
We report the observation of Raman solitons on numerical simulations of transient stimulated Raman scattering (TSRS) with small group velocity dispersion. The theory proceeds with the inverse scattering transform (IST) for initial-boundary value problems
Agrawall G P, Boiti M, F Pempinelli, J Leon, J-G Caputo, Levi D, M Boiti, Newell A C, Steudel H, Wenzel R G, Yariv A   +10 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The First Monograph on the History of the State Conference of 1917 Review of Gosudarstvennoe soveshchanie 1917 goda: sozyv, sostav, deyatel'nost' [The State Conference of 1917: convocation, composition, activities], by А.B. Nikolaev (St Petersburg: Asterion, 2022)

Historia provinciae: журнал региональной истории
The monograph under review is the first experience in researching the history of the preparation and conduct of the State Conference held in Moscow on August 12–15, 1917. A.
Fyodor A. Gayda
doaj   +1 more source

Uplink Sounding Reference Signal Coordination to Combat Pilot Contamination in 5G Massive MIMO

, 2017
To guarantee the success of massive multiple-input multiple-output (MIMO), one of the main challenges to solve is the efficient management of pilot contamination.
Baracca, Paolo, Campanalonga, Luca, Garcia-Rodriguez, Adrian, Geraci, Giovanni, Giordano, Lorenzo Galati, Lopez-Perez, David, Magarini, Maurizio   +6 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Hospitalization outcomes among brain metastasis patients receiving radiation therapy with or without stereotactic radiosurgery from the 2005–2014 Nationwide Inpatient Sample

Scientific Reports, 2021
The purpose of this study was to compare hospitalization outcomes among US inpatients with brain metastases who received stereotactic radiosurgery (SRS) and/or non-SRS radiation therapies without neurosurgical intervention.
Hind A. Beydoun, May A. Beydoun, Shuyan Huang, Shaker M. Eid, Alan B. Zonderman   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source