Emergency Laparoscopic Repair of Giant Left Diaphragmatic Hernia following Minimally Invasive Esophagectomy: Description of a Case and Review of the Literature [PDF]
Case Reports in Surgery, 2018 Postoperative diaphragmatic hernia (PDH) is an increasingly reported complication of esophageal cancer surgery. PDH occurs more frequently when minimally invasive techniques are employed, but very little is known about its pathogenesis.
Enrico Erdas +7 more
doaj +3 more sources
Special Issue “Advances in Antiviral Agents against SARS-CoV-2 and Its Variants” [PDF]
Viruses, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with 770 million reported cases and around 7 million deaths, represents the worst pandemic in the last 100 years [...]
Francesca Esposito, Rolando Cannalire
doaj +2 more sources
HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France) [PDF]
Pharmaceuticals, 2023 In this work we investigated, for the first time, the effect of Plagius flosculosus (L.) Alavi & Heywood, a Sardinian–Corsican endemic plant, on HIV-1 integrase (IN) activity.
Cinzia Sanna +8 more
doaj +2 more sources
Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships. [PDF]
Retrovirology, 2021 Zhang et al. (Proc Natl Acad Sci 118:e2105968118, 2021) recently reported that SARS-CoV-2 RNA can be retrotranscribed and integrated into the DNA of human cells by the L1 retrotransposon machinery.
Grandi N, Tramontano E, Berkhout B.
europepmc +3 more sources
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action [PDF]
Viruses, 2023 During the COVID-19 pandemic, drug repurposing represented an effective strategy to obtain quick answers to medical emergencies. Based on previous data on methotrexate (MTX), we evaluated the anti-viral activity of several DHFR inhibitors in two cell ...
Daniela Iaconis +17 more
doaj +3 more sources
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds [PDF]
Plants, 2021 In a search for natural compounds with anti-HIV-1 activity, we studied the effect of the ethanolic extract obtained from leaves, bark, and peels of Punica granatum L.
Cinzia Sanna +8 more
doaj +2 more sources
Long-term glucocorticoid treatment and high relapse rate remain unresolved issues in the real-life management of polymyalgia rheumatica: a systematic literature review and meta-analysis. [PDF]
Clin Rheumatol, 2022 A systematic review and meta-analysis were conducted, according to the PRISMA methodology, to summarize current evidence on the prevalence and predictors of long-term glucocorticoid (GC) treatment and disease relapses in the real-life management of ...
Floris A +7 more
europepmc +6 more sources
Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication [PDF]
Viruses, 2023 Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs.
Abhishek Asthana +10 more
doaj +2 more sources
Special Issue “Advances in Antiviral Agents Against SARS-CoV-2 and Its Variants” 2nd Edition [PDF]
VirusesSince the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), extensive efforts have been undertaken to identify effective therapeutic strategies to prevent and treat coronavirus disease 2019 (COVID-19) [...]
Francesca Esposito
doaj +2 more sources
Nutritional Status and Potentially Inappropriate Medications in Elderly. [PDF]
J Clin Med, 2022 (1) Background: The association between polypharmacy and malnutrition has been investigated in several studies; however, few of these specifically deepened the relationship between potentially inappropriate medication and malnutrition. With a descriptive
Loddo S +5 more
europepmc +3 more sources