Inhibitory effect of 2,3,5,6-tetrafluoro-4-[4-(Aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide derivatives on HIV reverse transcriptase associated rnase H activities [PDF]
, 2016 The HIV-1 ribonuclease H (RNase H) function of the reverse transcriptase (RT) enzyme catalyzes the selective hydrolysis of the RNA strand of the RNA:DNA heteroduplex replication intermediate, and represents a suitable target for drug development.
Carcelli, Mauro +10 more
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Contribution of type W human endogenous retroviruses to the human genome: Characterization of HERV-W proviral insertions and processed pseudogenes [PDF]
, 2016 Background: Human endogenous retroviruses (HERVs) are ancient sequences integrated in the germ line cells and vertically transmitted through the offspring constituting about 8% of our genome.
Blomberg, Jonas +3 more
core +6 more sources
Natural and Nature-Derived Products Targeting Human Coronaviruses [PDF]
, 2021 The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific community before a state of emergency that needs to be addressed with intensive research for the
Alexis, Michael N. +4 more
core +1 more source
Physical activity, exercise and sport programs as effective therapeutic tools in psychosocial rehabilitation [PDF]
, 2018 People with severe psychosocial disabilities have a 20-years shorter lifespan due to chronic somatic comorbidities and the long-term consequences of the side-effects of antipsychotic drugs.
Preti, A.
core +4 more sources
BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats [PDF]
, 2017 In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-DOPA-induced dyskinesia (LID), a motor ...
Björklund, Anders +7 more
core +1 more source
Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H [PDF]
, 2021 The bioactive components of Garcinia indica, garcinol (camboginol), and isogarcinol (cambogin), are suitable drug candidates for the treatment of various human diseases.
Biersack, Bernhard +6 more
core +1 more source
Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology [PDF]
, 2017 Human Endogenous Retroviruses (HERVs) are ancient infection relics constituting ~8% of our DNA. While HERVs' genomic characterization is still ongoing, impressive amounts of data have been obtained regarding their general expression across tissues. Among
Grandi, Nicole, Tramontano, Enzo
core +1 more source
Discordance between patient and physician global assessment of disease activity in Behçet's syndrome: a multicenter study cohort [PDF]
, 2021 Background: To compare the patients' and physician's global assessment of disease activity in Behçet's syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance.
Bertsias, George +20 more
core +1 more source
Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primates [PDF]
, 2020 Background: Endogenous Retroviruses (ERVs) constitute approximately 8% of every human genome and are relics of ancestral infections that affected the germ line cells.
Blomberg J. +6 more
core +1 more source
Attività biologica e studi di docking di derivati bis-ammidici dell'acido 5,6- diidrossiindolo-2-carbossilico come inibitori dell'enzima HIV-1 integrasi [PDF]
, 2002 In un precedente studio, nel tentativo di identificare nuovi inibitori dell'HIV-1 integrasi, è stata da noi considerata la modifica strutturale dell'estere feniletilico dell'acido caffeico I (CAPE), il primo prodotto naturale inibitore dell'IN ...
Angotzi, Gianfranco +9 more
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