Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa +17 more
wiley +1 more source
Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow. [PDF]
Transl PsychiatrySilberbauer LR +9 more
europepmc +1 more source
Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1331-1339, May 2026.Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar +9 more
wiley +1 more source
Comparative Real-World Safety Profiles of Six Selective Serotonin Reuptake Inhibitors: A Global Pharmacovigilance Analysis. [PDF]
CureusChan ACY.
europepmc +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield +5 more
wiley +1 more source
Pharmacogenetic Considerations in Sertraline Augmentation With Quetiapine in an Adolescent Woman With Obsessive-Compulsive Disorder, Autism Spectrum Disorder, and Attention-Deficit Hyperactivity Disorder: A Case Report. [PDF]
CureusAdegbola A, Dhir N, Ogunjobi O.
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha +2 more
wiley +1 more source
Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab +3 more
wiley +1 more source
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial. [PDF]
CNS DrugsSeynaeve M +6 more
europepmc +1 more source
Imaging of the serotonin transporter before and after citalopram administration in canine brain with 123I-betaCIT SPECT [PDF]
, 2004 Audenaert, Kurt +7 more
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