A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao +11 more
wiley +1 more source
Unusual Swelling Behavior of Hydrogels Modified with Spiropyran as Appendage or Crosslinker
Not so innocent after all—spiropyran crosslinkers in methylenebisacrylamide‐crosslinked poly(acrylamide‐co‐acrylic acid) hydrogels increase crosslinking density, but also, counterintuitively, increase swelling. Charge complexation, cooperative chemo‐mechanical effects, and aggregation may explain these observations.
Michael M. Lerch +7 more
wiley +1 more source
Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischaemic stroke [PDF]
Poster PresentationINTRODUCTION: Patients with myocardial infarction are at risk of development of atrial fibrillation (AF) and ischaemic stroke. We sought to evaluate the prognostic performance of the CHADS2 and CHA2DS2-VASc scores in predicting new AF ...
Chan, KH +9 more
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Spectrally Tunable 2D Material‐Based Infrared Photodetectors for Intelligent Optoelectronics
Intelligent optoelectronics through spectral engineering of 2D material‐based infrared photodetectors. Abstract The evolution of intelligent optoelectronic systems is driven by artificial intelligence (AI). However, their practical realization hinges on the ability to dynamically capture and process optical signals across a broad infrared (IR) spectrum.
Junheon Ha +18 more
wiley +1 more source
Acute Coronary Syndromes: Management and Secondary Prevention [PDF]
Acute coronary syndromes represent a broad spectrum of ischemic myocardial events including unstable angina, non-ST elevation myocardial infarction and acute ST elevation myocardial infarction, which are associated with high morbidity and mortality. They
Wenaweser, Peter, Windecker, Stephan
core
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
Quantifying the Area at Risk in Reperfused ST-Segment-Elevation Myocardial Infarction Patients Using Hybrid Cardiac Positron Emission Tomography-Magnetic Resonance Imaging [PDF]
BACKGROUND: Hybrid positron emission tomography and magnetic resonance allows the advantages of magnetic resonance in tissue characterizing the myocardium to be combined with the unique metabolic insights of positron emission tomography.
Bulluck, H +14 more
core
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava +7 more
wiley +1 more source
Electrochemically Driven Dissipative Growth of Affinity Hydrogels for Bioresponsive Interfaces
Voltage pulses drive the growth and reinforcement of hydrogel films under dissipative conditions. This biocompatible strategy enables efficient integration of affinity ligands into the hydrogel matrix, enhancing the selective capture of growth factors and allowing precise temporal control over their release, making them well‐suited as adaptive ...
Roberto Baretta, Marco Frasconi
wiley +1 more source
ST-segment elevation in lead aVR and acute coronary syndrome
Physicians often ignore lead aVR during ST segment analysis of ECG recordings as it supposedly carries no useful information.Occlusion of the left main coronary artery (LMCA) or the proximal part of left anterior descending artery (LAD) causes ischemia ...
Matija Žerdin, Matej Marinšek
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