Results 51 to 60 of about 203,870 (302)

Wandering ST-Segment Elevation [PDF]

Circulation, 2003
A 52-year-old man with a history of surgical repair of an abdominal aortic aneurysm 9 years earlier had a sudden onset of chest and back pain. His primary physician diagnosed acute myocardial infarction on the basis of ST elevation in leads V2 and V3 (Figure 1A). ST segments in leads I and aVL became elevated 30 minutes later, when chest pain worsened (
Takahiro Inoue, Yoshihiro Fukumoto, Masahiro Mohri, Kosuke Inokuchi, Yoji Hirakawa, Akira Takeshita   +5 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Usefulness of body surface mapping to differentiate patients with Brugada syndrome from patients with asymptomatic Brugada syndrome. [PDF]

, 2004
We attempted to determine the usefulness of body surface mapping (BSM) for differentiating patients with Brugada syndrome (BS) from patients with asymptomatic Brugada syndrome (ABS).
Emori, Tetsuro, Hisamatsu, Kenichi, Kusano, Kengo Fukushima, Matsubara, Hiromi, Morita, Hiroshi, Nagase, Satoshi, Nakamura, Kazufumi, Ohe, Tohru, Takenaka, Shiho   +8 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Significance of reciprocal ST segment depression in ST elevation myocardial infarction

Egyptian Journal of Critical Care Medicine, 2017
Background: The significance of reciprocal ST segment depression during acute myocardial infarction has been an area of debate, whether it is a sign of multivessel disease, ischemia at a distance or merely a benign electrical phenomenon.
Mahmoud K. Nour, MD
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Diffusely Elevated ST Segments on Electrocardiography [PDF]

JAMA Cardiology, 2016
A man in his early 70s walked into the emergency department with a 4-day history of fever and tingling sensation in the chest.Hismedical historywas significantwithhypertension, intracranial hemorrhage, and chronic kidneydisease (CKD).Onarrival, his bloodpressure was 130/64 mm Hg, heart rate was 104 beats/min, respiratory rate was 32 breaths/ min, body ...
Mitsuru, Mukaigawara, Kazuhito, Hirata, Minoru, Wake   +2 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ST-segment elevation and ventricular fibrillation shortly after transseptal puncture for left atrial catheter ablation

Journal of Arrhythmia, 2013
A 47-year-old man with drug-resistant paroxysmal atrial fibrillation underwent left atrial (LA) catheter ablation. After sheaths were inserted into the LA using the Brockenbrough method, he complained of angina and developed ST-segment elevation in the ...
Daisuke Ishigaki, MD, Takanori Arimoto, MD, Tadateru Iwayama, MD, Kutsuzawa Daisuke, MD, Yashiro Yoshinori, MD, Nitobe Joji, MD, Aoyama Hiroshi, MD, Watanabe Tetsu, MD, Kubota Isao, MD   +8 more
doaj   +1 more source

Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial. [PDF]

, 2015
Summary Background It is unclear whether radial compared with femoral access improves outcomes in unselected patients with acute coronary syndromes undergoing invasive management.
Andò G, Ausiello A, Briguori C, Brugaletta S, CALABRO' P, Colangelo S, Cortese B, de Cesare N, Esposito G, Frigoli E, Gagnor A, Galli M, Heg D, Ierna S, Jüni P, Leonardi S, Limbruno U, Lupi A, MATRIX Investigators., Nazzaro M, Palmieri C, Presbitero P, Rao SV, Repetto A, Rigattieri S, Rothenbühler M, Rubartelli P, Santarelli A, Sardella G, Sganzerla P, Tosi P, Tresoldi S, Valgimigli M, Varbella F, Vranckx P, Zaro T, Zingarelli A   +36 more
core   +1 more source